CAJ | 학술논문

目的：评价清肝泻火中药疗法治疗单疱病毒性角膜炎的临床疗效及安全性。方法将112例单疱病毒性角膜炎患者随机分为对照组52例（80只眼）和试验组60例（83只眼）。对照组予以阿昔洛韦滴眼液，每次0．05 mL，每天2次，0．5 mL为1个疗程，共2～3个疗程。试验组予以清肝泻火中药治疗，每天1剂，用3次煎煮的形式，第1，2次口服，第3次熏眼，5剂为1个疗程，共2～3个疗程。比较2组患者的临床疗效、视力以及不良反应发生率。结果试验组的临床总有效率98．79％显著高于对照组82．50％（ P＜0．05）。治疗后，试验组的视力明显优于对照组（P＜0．05）。2组患者不良反应发生率比较差异无统计学意义（ P＞0．05）。结论清肝泻火中药疗法治疗单疱病毒性角膜炎的临床疗效显著，且不增加不良反应的发生率。
목적：평개청간사화중약요법치료단포병독성각막염적림상료효급안전성。방법장112례단포병독성각막염환자수궤분위대조조52례（80지안）화시험조60례（83지안）。대조조여이아석락위적안액，매차0．05 mL，매천2차，0．5 mL위1개료정，공2～3개료정。시험조여이청간사화중약치료，매천1제，용3차전자적형식，제1，2차구복，제3차훈안，5제위1개료정，공2～3개료정。비교2조환자적림상료효、시력이급불량반응발생솔。결과시험조적림상총유효솔98．79％현저고우대조조82．50％（ P＜0．05）。치료후，시험조적시력명현우우대조조（P＜0．05）。2조환자불량반응발생솔비교차이무통계학의의（ P＞0．05）。결론청간사화중약요법치료단포병독성각막염적림상료효현저，차불증가불량반응적발생솔。
Objective To explore the clinical efficacy of traditional Chi-nese medicine therapy in the treatment of single blister viral keratitis. Methods One hundred twelve patients of single blister viral keratitis were randomly divided into control group ( n=52 , 80 eyes ) and treat-ment group ( n=60, 83 eyes).Patients in control group were given acy-clovir eye drops, each times was 0.05 mL bid, a period of treatment was 0.5 mL with 2 to 3 periods.Patients in treatment group were given clear-ing liver-fire traditional Chinese medicine therapy, 1 day 1 agent, 3 times with boiling form, the first and second oral, third smoked eyes, a period of treatment was 5 agents with 2 to 3 periods.Comparison of the clinical efficacy, vision and incidence of adverse drug reactions in two groups was performed.Results Total effective rate in treatment group was significantly higher than that in control group (98.79%vs 82.50%, P<0.05).After treatment, the vision was better than control group with statistically significant (P<0.05).The incidence of adverse drug reac-tions were not significantly different between two groups ( P >0.05 ) . Conclusion Clearing liver -fire traditional Chinese medicine therapy can improve the clinical efficacy without increasing the adverse drug reac-tions in the treatment of single blister viral keratitis.