CAJ | 학술논문

目的：探讨脂联素和 C 反应蛋白在妊娠期糖尿病患者早期诊断的应用情况，为妊娠期糖尿病患者的早期诊断提供依据。方法选取该院2012年12月至2013年12月收治的150例妊娠期糖尿病患者为研究对象，并选择同期150例健康孕妇的患者作为对照，观察患者孕早、中、晚期患者血清脂联素及 C 反应蛋白水平情况，并以健康孕妇组作为对照。结果妊娠期糖尿病患者血清脂联素水平明显低于健康孕妇组，而 C 反应蛋白的水平明显高于健康孕妇组，差异均有统计学意义（P＜0．05）；健康孕妇组中，随着孕周的增加，脂联素水平呈现出逐渐下降的趋势（P＜0．05），而 C 反应蛋白水平随着孕周的增加无明显变化（P＞0．05）；妊娠期糖尿病孕妇组中，脂联素与 C 反应蛋白水平随孕周增加均逐渐下降（P＜0．05）。与健康孕妇组相比，妊娠期糖尿病孕妇组在孕早期、中期和孕晚期的脂联素水平明显降低，而 C 反应蛋白水平明显增加（P＜0．05）。结论妊娠期糖尿病患者血中脂联素水平明显低于健康孕妇组，而 C 反应蛋白明显高于健康孕妇组，两者的早期监测可以为妊娠期糖尿病患者的早期诊断提供依据，值得临床进一步探讨和研究。
목적：탐토지련소화 C 반응단백재임신기당뇨병환자조기진단적응용정황，위임신기당뇨병환자적조기진단제공의거。방법선취해원2012년12월지2013년12월수치적150례임신기당뇨병환자위연구대상，병선택동기150례건강잉부적환자작위대조，관찰환자잉조、중、만기환자혈청지련소급 C 반응단백수평정황，병이건강잉부조작위대조。결과임신기당뇨병환자혈청지련소수평명현저우건강잉부조，이 C 반응단백적수평명현고우건강잉부조，차이균유통계학의의（P＜0．05）；건강잉부조중，수착잉주적증가，지련소수평정현출축점하강적추세（P＜0．05），이 C 반응단백수평수착잉주적증가무명현변화（P＞0．05）；임신기당뇨병잉부조중，지련소여 C 반응단백수평수잉주증가균축점하강（P＜0．05）。여건강잉부조상비，임신기당뇨병잉부조재잉조기、중기화잉만기적지련소수평명현강저，이 C 반응단백수평명현증가（P＜0．05）。결론임신기당뇨병환자혈중지련소수평명현저우건강잉부조，이 C 반응단백명현고우건강잉부조，량자적조기감측가이위임신기당뇨병환자적조기진단제공의거，치득림상진일보탐토화연구。
Objective To investigate the application situation of adiponectin and C‐reactive protein(CRP) de‐tection in the early diagnosis of gestational diabetes(GD) to provide to the basis for its early diagnosis .Methods 150 cases of gestational diabetes(GD) in our hospital from December 2012 to December 2013 were selected as the re‐search subjects ,and contemporaneous 150 healthy pregnant women were selected as the control group .Then the lev‐els of serum adiponectin and CRP in the early ,middle and late stage of pregnancy were observed and compared with those in the control group .Results Serum adiponectin level in the GD group was significantly lower than that in the control group ,while the CRP level was significantly higher than that in the control group ,the differences were statis‐tically (P< 0 .05) ;in the control group ,with the gestation increase ,the adiponectin level showed the gradually de‐creasing trend(P< 0 .05) ,while the CRP level had no obvious change(P > 0 .05) ;in the GD group ,the adiponectin and CRP levels were gradually decreased with the gestation increase ,the difference was statistically significant(P<0 .05) ;compared with the control group ,the adiponectin levels in the early ,middle and late stages of gestation in the GD group were significantly decreased ,while the CRP levels weresignificantly increased(P> 0 .05) .Conclusion Ser‐um adiponectin level in GD is significantly lower than that in the normal pregnant women ,while the CRP level is sig‐nificantly higher than that in the normal pregnant women .Therefore their early monitoring can provide the basis for the early diagnosis of GD and is worth further discussion and study .