热带病与寄生虫学
熱帶病與寄生蟲學
열대병여기생충학
Journal of Tropical Diseases and Parasitology
2015年
3期
169-171
,共3页
日本血吸虫病%吡喹酮薄膜衣片%敏感性%疗效
日本血吸蟲病%吡喹酮薄膜衣片%敏感性%療效
일본혈흡충병%필규동박막의편%민감성%료효
Schistosomiasis japonica%Film-coated praziquantel tablet%Sensitivity%Therapeutic effi-cacy
目的：评价日本血吸虫病低度流行区吡喹酮薄膜衣片对血吸虫病患者的疗效。方法选择1个血吸虫病低度流行村，对5~60岁常住居民采用毛蚴孵化法进行粪检，并统计患者感染度（EPG）。阳性者分别采用60mg/kg或40mg/kg吡喹酮薄膜衣片进行病原学治疗。治疗6周后粪检复查，评估吡喹酮薄膜衣片疗效，阳性者采用相同治疗进行第2次治疗；同时观察吡喹酮服药后的不良反应发生情况。结果87例观察对象中，有吡喹酮抗虫治疗史1次者43例，2次以上者44例；中度感染37例（EPG：216~312），轻度感染50例（ EPG：24~96）；第1次治疗使用吡喹酮薄膜衣片60mg/kg 37例，40mg/kg 50例，复查均未查见毛蚴或虫卵。患者不良反应发生率为17.24%。结论在日本血吸虫病低度流行区，吡喹酮薄膜衣片对血吸虫感染者具有较高敏感性。
目的：評價日本血吸蟲病低度流行區吡喹酮薄膜衣片對血吸蟲病患者的療效。方法選擇1箇血吸蟲病低度流行村，對5~60歲常住居民採用毛蚴孵化法進行糞檢，併統計患者感染度（EPG）。暘性者分彆採用60mg/kg或40mg/kg吡喹酮薄膜衣片進行病原學治療。治療6週後糞檢複查，評估吡喹酮薄膜衣片療效，暘性者採用相同治療進行第2次治療；同時觀察吡喹酮服藥後的不良反應髮生情況。結果87例觀察對象中，有吡喹酮抗蟲治療史1次者43例，2次以上者44例；中度感染37例（EPG：216~312），輕度感染50例（ EPG：24~96）；第1次治療使用吡喹酮薄膜衣片60mg/kg 37例，40mg/kg 50例，複查均未查見毛蚴或蟲卵。患者不良反應髮生率為17.24%。結論在日本血吸蟲病低度流行區，吡喹酮薄膜衣片對血吸蟲感染者具有較高敏感性。
목적：평개일본혈흡충병저도류행구필규동박막의편대혈흡충병환자적료효。방법선택1개혈흡충병저도류행촌，대5~60세상주거민채용모유부화법진행분검，병통계환자감염도（EPG）。양성자분별채용60mg/kg혹40mg/kg필규동박막의편진행병원학치료。치료6주후분검복사，평고필규동박막의편료효，양성자채용상동치료진행제2차치료；동시관찰필규동복약후적불량반응발생정황。결과87례관찰대상중，유필규동항충치료사1차자43례，2차이상자44례；중도감염37례（EPG：216~312），경도감염50례（ EPG：24~96）；제1차치료사용필규동박막의편60mg/kg 37례，40mg/kg 50례，복사균미사견모유혹충란。환자불량반응발생솔위17.24%。결론재일본혈흡충병저도류행구，필규동박막의편대혈흡충감염자구유교고민감성。
Objective To evaluate the therapeutic efficacy of film-coated praziquantel tablet in the treat?ment of patients infected with Schistosoma japonicum(S. japonicum) in areas with low endemicity. Methods The dwellers aged 5 to 60 years from villages of low endemicity received stool examination for the S. japoni?cum infection using miracidium hatching test, and the positive cases were given etiological intervention with film-coated praziquantel tablet in dose of 60 or 40 mg/kg. Miracidium hatching test was performed after 6 weeks of medication to assess the therapeutic efficacy, and those that remained positive underwent the second treatment using the same protocol. All adverse events associated with praziquantel treatment were observed. Results Of the 87 subjects, 43 had a history of once praziquantel treatment, and 44 a history of twice or over. Thirty-seven cases had moderate infection (EPG, 216-312), and 50 mild infection (EPG, 24-96). Re-exami?nation with miracidium hatching test detected no S. japonicum miradium or egg following treatment with film-coated praziquantel tablet in dose of 60 mg/kg in 37 cases and 40 mg/kg in 50 cases. The incidence of adverse reactions was 17.24%. Conclusion The therapeutic efficacy of film-coated praziquantel tablet remains sensitive to patients infected with S. japonicum in areas with low endemicity.
