检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
18期
2731-2733
,共3页
类风湿关节炎%诊断%治疗%影像学方法
類風濕關節炎%診斷%治療%影像學方法
류풍습관절염%진단%치료%영상학방법
rheumatoid arthritis%diagnosis%treatment%imaging methods
目的:研究 MRI 、CT 等影像学诊断在类风湿关节炎患者诊断、治疗及预后评估中的应用情况。方法选取70例类风湿关节炎患者,收集患者的临床资料,对相关抗体、炎性反应指标进行检查,评价疾病活动情况,同时实施 MRI 、SPECT /CT 等影像学检查,对 MRI 图像按 RAMRIS 系统评分,对骨代谢增加区域行感兴趣区(ROI)分析计算摄取率,并就相关数据进行统计学分析。结果 SDAI 与 RAMRIS 的 Spearman 相关性:滑膜炎(ρ=0.391,P<0.05),骨髓水肿(ρ=0.402,P<0.05),侵蚀(ρ=0.329,P=0.006)。在 SDAI <11(低疾病活动度和缓解患者)和 SDAI ≥11(中、重度疾病活动患者)组间 RAMRIS 评分有差异(P =0.002)。但在低疾病活动和缓解患者之间,中度和重度活动患者之间 MRI 评分差异无统计学意义。 SPECT /CT 摄取率与患者体内炎性因子 ESR 、CRP 均有相关性,ESR(ρ=0.343,P<0.05),CRP(ρ=0.431,P<0.05);摄取率与抗炎因子 AKA 也明显相关(ρ=0.263,P<0.05)。此外,摄取率与疾病活动程度 SDAI 也明显相关(ρ=0.355,P<0.05)。结论 MRI 、CT 等影像学方法有助于早期诊断类风湿关节炎,MRI 以及 SPECT /CT 的摄取率对评价类风湿关节炎进展、预后都有积极意义。
目的:研究 MRI 、CT 等影像學診斷在類風濕關節炎患者診斷、治療及預後評估中的應用情況。方法選取70例類風濕關節炎患者,收集患者的臨床資料,對相關抗體、炎性反應指標進行檢查,評價疾病活動情況,同時實施 MRI 、SPECT /CT 等影像學檢查,對 MRI 圖像按 RAMRIS 繫統評分,對骨代謝增加區域行感興趣區(ROI)分析計算攝取率,併就相關數據進行統計學分析。結果 SDAI 與 RAMRIS 的 Spearman 相關性:滑膜炎(ρ=0.391,P<0.05),骨髓水腫(ρ=0.402,P<0.05),侵蝕(ρ=0.329,P=0.006)。在 SDAI <11(低疾病活動度和緩解患者)和 SDAI ≥11(中、重度疾病活動患者)組間 RAMRIS 評分有差異(P =0.002)。但在低疾病活動和緩解患者之間,中度和重度活動患者之間 MRI 評分差異無統計學意義。 SPECT /CT 攝取率與患者體內炎性因子 ESR 、CRP 均有相關性,ESR(ρ=0.343,P<0.05),CRP(ρ=0.431,P<0.05);攝取率與抗炎因子 AKA 也明顯相關(ρ=0.263,P<0.05)。此外,攝取率與疾病活動程度 SDAI 也明顯相關(ρ=0.355,P<0.05)。結論 MRI 、CT 等影像學方法有助于早期診斷類風濕關節炎,MRI 以及 SPECT /CT 的攝取率對評價類風濕關節炎進展、預後都有積極意義。
목적:연구 MRI 、CT 등영상학진단재류풍습관절염환자진단、치료급예후평고중적응용정황。방법선취70례류풍습관절염환자,수집환자적림상자료,대상관항체、염성반응지표진행검사,평개질병활동정황,동시실시 MRI 、SPECT /CT 등영상학검사,대 MRI 도상안 RAMRIS 계통평분,대골대사증가구역행감흥취구(ROI)분석계산섭취솔,병취상관수거진행통계학분석。결과 SDAI 여 RAMRIS 적 Spearman 상관성:활막염(ρ=0.391,P<0.05),골수수종(ρ=0.402,P<0.05),침식(ρ=0.329,P=0.006)。재 SDAI <11(저질병활동도화완해환자)화 SDAI ≥11(중、중도질병활동환자)조간 RAMRIS 평분유차이(P =0.002)。단재저질병활동화완해환자지간,중도화중도활동환자지간 MRI 평분차이무통계학의의。 SPECT /CT 섭취솔여환자체내염성인자 ESR 、CRP 균유상관성,ESR(ρ=0.343,P<0.05),CRP(ρ=0.431,P<0.05);섭취솔여항염인자 AKA 야명현상관(ρ=0.263,P<0.05)。차외,섭취솔여질병활동정도 SDAI 야명현상관(ρ=0.355,P<0.05)。결론 MRI 、CT 등영상학방법유조우조기진단류풍습관절염,MRI 이급 SPECT /CT 적섭취솔대평개류풍습관절염진전、예후도유적겁의의。
Objective To investigate the application situation of imaging diagnosis of MRI ,CT ,etc .in rheuma‐toid arthritis(RA) .Methods 70 patients with RA in our hospital were selected and their clinical data were collected . The related antibodies and inflammatory reaction indicators were detected .The disease activity situation was as‐sessed .At the same time the imaging examinations such as MRI and SPECT /CT were performed .The MRI images were scored according to the RAMRIS system .The bone metabolism increasing area was performed the region of in‐terest (ROI) analysis for calculating the uptake ratio of ROI .Results The Spearman correlation of SDAI and RAM‐RIS :synovitis (ρ = 0 .391 ,P< 0 .05) ,bone marrow edema(BME) (ρ = 0 .402 ,P< 0 .05) and erosion(ρ = 0 .329 ,P=0 .006) .The RAMRIS score had statistical difference between SDAI < 11 (low disease activity and remission) and SDAI ≥ 11 group(moderate and severe disease activity) (P= 0 .002) .The SPECT /CT in vivo uptake had the correla‐tion with the body inflammatory factors of ESR and CRP (ρ = 0 .343 ,P< 0 .05 ,ρ = 0 .431 ,P< 0 .05) ;and the uptake was also significantly correlated with the anti‐inflammatory cytokine AKA (ρ = 0 .263 ,P< 0 .05) .In addition ,the up‐take rate was also significantly correlated with the disease activity SDAI(ρ = 0 .355 ,P< 0 .05) .Conclusion The ima‐ging methods of MRI and CT conduce to early diagnosis of RA and the uptake rate of MRI and SPECT /CT has posi‐tive significance to evaluate the progression and prognosis of RA .