国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
International Journal of Laboratory Medicine
2015年
17期
2516-2518
,共3页
再生障碍性贫血%辅助性T淋巴细胞%调节性T淋巴细胞%炎性因子
再生障礙性貧血%輔助性T淋巴細胞%調節性T淋巴細胞%炎性因子
재생장애성빈혈%보조성T림파세포%조절성T림파세포%염성인자
aplastic anemia%helper T cell%regulatory T cells%inflammatory factor
目的：研究T淋巴细胞亚群与炎性因子检测在再生障碍性贫血（A A ）病情及预后评估中的价值。方法选取本院收治的40例AA患者作为AA组，并进一步分为急性再生障碍性贫血（AAA）组和慢性再生障碍性贫血（CAA）组；同时选取同期于本院体检的40例健康者作为对照组。比较两组患者的血常规指标、外周血 T 淋巴细胞亚群百分率和血清炎性因子水平。结果 AA组患者外周血辅助性T淋巴细胞（Th）Th1、Th17细胞百分率及 Th1／Th2、Th17／调节性T淋巴细胞（Treg）比例均高于对照组（P＜0．05），Th2、Treg细胞百分率低于对照组（P＜0．05）；AAA组外周血 Th1、Th17细胞百分率及 Th1／Th2、Th17／Treg比例高于CAA组，Th2、Treg细胞水平低于CAA组（P＜0．05）。AA组患者血清白细胞介素（IL）‐2、IFN‐γ、IL‐17水平高于对照组，IL‐4、IL‐6、IL‐10水平低于对照组，差异均有统计学意义（P＜0．05）；AAA 组血清中IL‐2、干扰素‐γ（IFN‐γ）、IL‐17水平高于CAA组，IL‐4、IL‐6、IL‐10水平低于CAA组，差异均有统计学意义（P＜0．05）；血红蛋白（Hb）水平、PTL与 Th1、Th17细胞水平及IL‐2、IFN‐γ、IL‐17水平呈负相关，与Th2、Treg细胞水平及IL‐4、IL‐6、IL‐10水平呈正相关。结论 AA患者外周血中 T淋巴细胞亚群百分率及血清炎性因子水平存在异常，而且与反映病情严重程度及预后的指标具有良好的相关性。
目的：研究T淋巴細胞亞群與炎性因子檢測在再生障礙性貧血（A A ）病情及預後評估中的價值。方法選取本院收治的40例AA患者作為AA組，併進一步分為急性再生障礙性貧血（AAA）組和慢性再生障礙性貧血（CAA）組；同時選取同期于本院體檢的40例健康者作為對照組。比較兩組患者的血常規指標、外週血 T 淋巴細胞亞群百分率和血清炎性因子水平。結果 AA組患者外週血輔助性T淋巴細胞（Th）Th1、Th17細胞百分率及 Th1／Th2、Th17／調節性T淋巴細胞（Treg）比例均高于對照組（P＜0．05），Th2、Treg細胞百分率低于對照組（P＜0．05）；AAA組外週血 Th1、Th17細胞百分率及 Th1／Th2、Th17／Treg比例高于CAA組，Th2、Treg細胞水平低于CAA組（P＜0．05）。AA組患者血清白細胞介素（IL）‐2、IFN‐γ、IL‐17水平高于對照組，IL‐4、IL‐6、IL‐10水平低于對照組，差異均有統計學意義（P＜0．05）；AAA 組血清中IL‐2、榦擾素‐γ（IFN‐γ）、IL‐17水平高于CAA組，IL‐4、IL‐6、IL‐10水平低于CAA組，差異均有統計學意義（P＜0．05）；血紅蛋白（Hb）水平、PTL與 Th1、Th17細胞水平及IL‐2、IFN‐γ、IL‐17水平呈負相關，與Th2、Treg細胞水平及IL‐4、IL‐6、IL‐10水平呈正相關。結論 AA患者外週血中 T淋巴細胞亞群百分率及血清炎性因子水平存在異常，而且與反映病情嚴重程度及預後的指標具有良好的相關性。
목적：연구T림파세포아군여염성인자검측재재생장애성빈혈（A A ）병정급예후평고중적개치。방법선취본원수치적40례AA환자작위AA조，병진일보분위급성재생장애성빈혈（AAA）조화만성재생장애성빈혈（CAA）조；동시선취동기우본원체검적40례건강자작위대조조。비교량조환자적혈상규지표、외주혈 T 림파세포아군백분솔화혈청염성인자수평。결과 AA조환자외주혈보조성T림파세포（Th）Th1、Th17세포백분솔급 Th1／Th2、Th17／조절성T림파세포（Treg）비례균고우대조조（P＜0．05），Th2、Treg세포백분솔저우대조조（P＜0．05）；AAA조외주혈 Th1、Th17세포백분솔급 Th1／Th2、Th17／Treg비례고우CAA조，Th2、Treg세포수평저우CAA조（P＜0．05）。AA조환자혈청백세포개소（IL）‐2、IFN‐γ、IL‐17수평고우대조조，IL‐4、IL‐6、IL‐10수평저우대조조，차이균유통계학의의（P＜0．05）；AAA 조혈청중IL‐2、간우소‐γ（IFN‐γ）、IL‐17수평고우CAA조，IL‐4、IL‐6、IL‐10수평저우CAA조，차이균유통계학의의（P＜0．05）；혈홍단백（Hb）수평、PTL여 Th1、Th17세포수평급IL‐2、IFN‐γ、IL‐17수평정부상관，여Th2、Treg세포수평급IL‐4、IL‐6、IL‐10수평정정상관。결론 AA환자외주혈중 T림파세포아군백분솔급혈청염성인자수평존재이상，이차여반영병정엄중정도급예후적지표구유량호적상관성。
Objective To study the application value of T lymphocyte subsets and inflammatory factors in evaluating severity andprognosisofaplasticanemia.Methods 40patientswithaplasticanemiainthehospitalwereenrolledinthestudyasAAgroup, which was further divided into acute aplastic anemia(AAA) subgroup and chronic aplastic anemia(CAA) subgroup .In addition to that ,40 healthy people who received physical examination in the hospital during the same period were enrolled in the study as con‐trol group .Then blood routine tests were performed ,T lymphocyte subsets content in peripheral blood and serum inflammatory fac‐tor content were detected and the results were compared .Results Th1 ,Th17 contents and Th1/Th2 ,Th17/Treg ratio in AA group were higher than those in control group(P<0 .05) ,while Th2 ,Treg contents were lower(P<0 .05);Th1 ,Th17 contents and Th1/Th2 ,Th17/Treg ratio in AAA group were higher than those in CAA group(P<0 .05) ,while Th2 ,Treg cells contents were lower . Serum IL‐2 ,IFN‐γ ,IL‐17 contents in AA group were higher than those in control group(P<0 .05) ,while IL‐4 ,IL‐6 ,IL‐10 contents were lower(P<0 .05);serum IL‐2 ,IFN‐γ,IL‐17 contents in AAA group were higher than those of CAA group ,while IL‐4 ,IL‐6 , IL‐10 contents were lower .Hb ,PTL contents were negatively correlated with Th1 ,Th17 contents and serum IL‐2 ,IFN‐γ ,IL‐17 contents ,while positively correlated with Th2 ,Treg cells contents and serum IL‐4 ,IL‐6 ,IL‐10 contents .Conclusion Peripheral blood T lymphocyte subsets and serum inflammatory factors contents in aplastic anemia are abnormal and are correlated with the severity and prognosis related indicators .
