CAJ | 학술논문

目的：探讨全自动血细胞分析仪Sysmex XE‐2100检测外周血所得白细胞研究性参数对初诊乙型肝炎患者的临床意义。方法选取感染科门诊96例初诊乙型肝炎患者（观察组）和100例同期健康体检人群（对照组）作为研究对象。对上述人群进行相关指标的检测，如乙型肝炎病毒DNA（HBV‐DNA）、乙型肝炎表面抗原（HBsAg）、天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT），淋巴细胞参数 Lymph‐Y、Lymph‐X ，中性粒细胞参数 Neut‐Y、Neut‐X ，记录检测结果并通过统计学软件SPSS19．0进行统计学数据处理、分析。结果观察组与对照组比较，Lymph‐X、Neut‐Y、Neut‐X差异无统计学意义（P＞0．05），而HBV‐DNA、HBsAg、AST、ALT、Lymph‐Y各检测指标两组间比较，差异有统计学意义（P＜0．05），并且参数Lymph‐Y与 HBV‐DNA（r＝0．160，P＝0．026）和 HBsAg（r＝0．149，P＝0．037）均呈正相关。结论初诊乙型肝炎患者外周血淋巴细胞参数Lymph‐Y高于健康人群，可能是一个潜在的用于鉴别诊断的指标。
목적：탐토전자동혈세포분석의Sysmex XE‐2100검측외주혈소득백세포연구성삼수대초진을형간염환자적림상의의。방법선취감염과문진96례초진을형간염환자（관찰조）화100례동기건강체검인군（대조조）작위연구대상。대상술인군진행상관지표적검측，여을형간염병독DNA（HBV‐DNA）、을형간염표면항원（HBsAg）、천동안산안기전이매（AST）、병안산안기전이매（ALT），림파세포삼수 Lymph‐Y、Lymph‐X ，중성립세포삼수 Neut‐Y、Neut‐X ，기록검측결과병통과통계학연건SPSS19．0진행통계학수거처리、분석。결과관찰조여대조조비교，Lymph‐X、Neut‐Y、Neut‐X차이무통계학의의（P＞0．05），이HBV‐DNA、HBsAg、AST、ALT、Lymph‐Y각검측지표량조간비교，차이유통계학의의（P＜0．05），병차삼수Lymph‐Y여 HBV‐DNA（r＝0．160，P＝0．026）화 HBsAg（r＝0．149，P＝0．037）균정정상관。결론초진을형간염환자외주혈림파세포삼수Lymph‐Y고우건강인군，가능시일개잠재적용우감별진단적지표。
Objective To study the clinical significance of leukocyte parameters measured by using automatic blood cell analyzer SysmexXE‐2100inpatientsnewlydiagnosedwithhepatitisB.Methods 96patientsnewlydiagnosedwithhepatitisB(observation group) and 100 people who underwent healthy examination during the same period(control group) were recruited in the study .Rel‐ative indicators were measured for the people mentioned above ,such as the DNA of Hepatitis B virus(HBV‐DNA) ,Hepatitis B sur‐face antigen(HBsAg) ,aspartate aminotransferase(AST ) ,alanine aminotransferase(ALT ) ,lymphocytes parameters Lymph‐Y and Lymph‐X ,neutrophils parameters Neut‐X and Neut‐Y .The test results were recorded and statistically analyzed by using software SPSS19 .0 .Results The differences of Lymph‐X ,Neut‐Y and Neut‐X were not statistically significant compared between observa‐tion group and control group(P>0 .05) ,while the differences of HBV‐DNA ,HBsAg ,AST ,ALT and Lymph‐Y were statistically significant compared between the two groups(P<0 .05) .In addition to that ,the parameter Lymph‐Y was positirely correlated with HBV‐DNA(r=0 .160 ,P=0 .026) and HBsAg(r=0 .149 ,P=0 .037) .Conclusion The peripheral blood lymphocytes parameter Lymph‐Y of patients newly diagnosed with hepatitis B is higher than healthy people ,which makes it possible to become an indicator for differential diagnosis .