CAJ | 학술논문

大量流行病学研究认为COPD与心血管疾病之间有着密切联系.COPD并发心血管疾病的机制复杂多样,除了与系统性炎症反应有关,还可能与氧化应激、交感神经兴奋性增加、血管壁异常、血液高凝状态和血小板活化、衰老速度加快、蛋白酶/抗蛋白酶平衡失调等有关.COPD并发心血管疾病的治疗包括吸氧、运动、β受体激动剂及阻滞剂、抗血小板治疗、他汀类药物、抗氧化应激治疗等.本文就COPD合并心血管疾病的发生机制及其治疗进展作一综述.
대량류행병학연구인위COPD여심혈관질병지간유착밀절련계.COPD병발심혈관질병적궤제복잡다양,제료여계통성염증반응유관,환가능여양화응격、교감신경흥강성증가、혈관벽이상、혈액고응상태화혈소판활화、쇠로속도가쾌、단백매/항단백매평형실조등유관.COPD병발심혈관질병적치료포괄흡양、운동、β수체격동제급조체제、항혈소판치료、타정류약물、항양화응격치료등.본문취COPD합병심혈관질병적발생궤제급기치료진전작일종술.
Numerous epidemiologic studies have dose linked the presence of chronic obstructive pulmonary disease (COPD) to cardiovascular disease.The mechanisms responsible for the increased risk of cardiovascular disease in patients with COPD are complex,not only associated with systemic inflammatory response,but also with oxidative stress,sympathetic overactivity,abnormalities of the vascular wall,blood high condensation state and platelet activation,accelerated aging,protease/ antiprotease imbalance and so on.The treatment of COPD with cardiovascular diseases including oxygen,exercise,beta agonists and blockers,antiplatelet therapy,statins,antioxidant stress treatment,etc.In this paper,COPD merger of cardiovascular disease mechanisms,therapy were reviewed.