西北药学杂志
西北藥學雜誌
서북약학잡지
Northwest Pharmaceutical Journal
2015年
5期
621-623
,共3页
埃索美拉唑%十二指肠溃疡%幽门螺旋杆菌%胃肠功能%免疫功能
埃索美拉唑%十二指腸潰瘍%幽門螺鏇桿菌%胃腸功能%免疫功能
애색미랍서%십이지장궤양%유문라선간균%위장공능%면역공능
esomeprazole%duodenal ulcer%Helicobacter pylori%gastrointestinal function%immune function
目的:研究埃索美拉唑三联疗法对幽门螺杆菌阳性十二指肠溃疡免疫功能及胃肠功能的影响。方法将我院收治的110例幽门螺杆菌阳性十二指肠溃疡患者纳入研究对象,采用随机数字表法分为观察组和对照组各55例,观察组患者接受埃索美拉唑三联治疗,对照组患者接受奥美拉唑三联治疗,比较2组患者的胃肠功能、免疫功能、生存质量。结果胃肠功能:观察组患者腹胀缓解时间及腹痛缓解时间短于对照组(6.23±0.84vs10.39±1.25,3.84±0.47vs6.91±0.88)d,溃疡愈合好转率明显高于对照组(98.12%vs78.18%);免疫功能:观察组患者的CD3+T细胞、CD4+T细胞含量高于对照组(54.42±6.42vs48.26±6.12,44.19±5.28vs39.56±4.08),CD8+T细胞含量低于对照组(24.32±2.72vs26.48±3.31);生存质量:观察组患者的物质生活维度(54.18±6.68vs47.44±5.43)、躯体健康维度(64.52±7.51vs51.85±6.04)、心理健康维度(67.38±7.83vs53.48±6.14)、社会功能维度(62.22±7.87vs53.45±6.52)评分均高于对照组患者。结论埃索美拉唑三联疗法有助于迅速缓解患者临床症状,改善胃肠功能和免疫功能,提高生存质量。
目的:研究埃索美拉唑三聯療法對幽門螺桿菌暘性十二指腸潰瘍免疫功能及胃腸功能的影響。方法將我院收治的110例幽門螺桿菌暘性十二指腸潰瘍患者納入研究對象,採用隨機數字錶法分為觀察組和對照組各55例,觀察組患者接受埃索美拉唑三聯治療,對照組患者接受奧美拉唑三聯治療,比較2組患者的胃腸功能、免疫功能、生存質量。結果胃腸功能:觀察組患者腹脹緩解時間及腹痛緩解時間短于對照組(6.23±0.84vs10.39±1.25,3.84±0.47vs6.91±0.88)d,潰瘍愈閤好轉率明顯高于對照組(98.12%vs78.18%);免疫功能:觀察組患者的CD3+T細胞、CD4+T細胞含量高于對照組(54.42±6.42vs48.26±6.12,44.19±5.28vs39.56±4.08),CD8+T細胞含量低于對照組(24.32±2.72vs26.48±3.31);生存質量:觀察組患者的物質生活維度(54.18±6.68vs47.44±5.43)、軀體健康維度(64.52±7.51vs51.85±6.04)、心理健康維度(67.38±7.83vs53.48±6.14)、社會功能維度(62.22±7.87vs53.45±6.52)評分均高于對照組患者。結論埃索美拉唑三聯療法有助于迅速緩解患者臨床癥狀,改善胃腸功能和免疫功能,提高生存質量。
목적:연구애색미랍서삼련요법대유문라간균양성십이지장궤양면역공능급위장공능적영향。방법장아원수치적110례유문라간균양성십이지장궤양환자납입연구대상,채용수궤수자표법분위관찰조화대조조각55례,관찰조환자접수애색미랍서삼련치료,대조조환자접수오미랍서삼련치료,비교2조환자적위장공능、면역공능、생존질량。결과위장공능:관찰조환자복창완해시간급복통완해시간단우대조조(6.23±0.84vs10.39±1.25,3.84±0.47vs6.91±0.88)d,궤양유합호전솔명현고우대조조(98.12%vs78.18%);면역공능:관찰조환자적CD3+T세포、CD4+T세포함량고우대조조(54.42±6.42vs48.26±6.12,44.19±5.28vs39.56±4.08),CD8+T세포함량저우대조조(24.32±2.72vs26.48±3.31);생존질량:관찰조환자적물질생활유도(54.18±6.68vs47.44±5.43)、구체건강유도(64.52±7.51vs51.85±6.04)、심리건강유도(67.38±7.83vs53.48±6.14)、사회공능유도(62.22±7.87vs53.45±6.52)평분균고우대조조환자。결론애색미랍서삼련요법유조우신속완해환자림상증상,개선위장공능화면역공능,제고생존질량。
Objective To study the effect of esomeprazole triple therapy on immune function and gastrointestinal function of Helico‐bacter pylori positive duodenal ulcer .Methods 110 cases of Helicobacter pylori positive duodenal ulcer patients in our hospital were enrolled and randomly divided into observation group and control group .The observation group received esomeprazole triple therapy ,while the control group received omeprazole triple therapy .Then gastrointestinal function ,immune function ,and quality of life were compared .Results Gastrointestinal function :observation group ,abdominal distension and pain relieving time were shorter than those of control group (6 .23 ± 0 .84 vs 10 .39 ± 1 .25 ,3 .84 ± 0 .47 vs 6 .91 ± 0 .88) d ,ulcer healing was significantly better than that of control group (98 .12% vs 78 .18% );Immune function :observation group ,CD3+ T cells ,CD4+ T cells con‐tents were higher than those of control group (54 .42 ± 6 .42 vs 48 .26 ± 6 .12 ,44 .19 ± 5 .28 vs 39 .56 ± 4 .08) ,CD8+ T cells con‐tent was lower than that of control group (24 .32 ± 2 .72 vs 26 .48 ± 3 .31);Survival quality :observation group ,material life di‐mension ,physical health dimension ,mental health dimension ,social function dimensions scores were higher than those of control group(54.18±6.68vs47.44±5.43,64.52±7.51vs51.85±6.04,67.38±7.83vs53.48±6.14,62.22±7.87vs53.45± 6 .52) .Conclusion Esomeprazole triple therapy could help to quickly relieve the clinical symptoms ,improve gastrointestinal func‐tion and immune function ,therefore improve the survival quality .