西北药学杂志
西北藥學雜誌
서북약학잡지
Northwest Pharmaceutical Journal
2015年
5期
618-620
,共3页
乌司他丁%脓毒症休克%血常规%乳酸(L A )%降钙素原(PC T )
烏司他丁%膿毒癥休剋%血常規%乳痠(L A )%降鈣素原(PC T )
오사타정%농독증휴극%혈상규%유산(L A )%강개소원(PC T )
ulinastatin%septic shock%blood routine%lactic acid%procalcitonin
目的：探讨乌司他丁对脓毒症休克患者血常规、血乳酸（L A ）及降钙素原（PC T ）的影响。方法根据随机数字表法将2011年3月～2014年10月我院收治的130例脓毒症休克患者分为对照组（65例）与观察组（65例），对照组接受脓毒症休克的常规治疗，观察组在常规治疗基础上联合使用乌司他丁，对比分析2组患者的治疗效果。结果①治疗前，2组患者白细胞计数（WBC）、中性粒细胞计数（NEU＃）、中性粒细胞比值（NEU％）、LA、PCT、C反应蛋白（CRP）相比，差异无统计学意义。治疗7 d后，观察组WBC、NEU＃、NEU％、LA、PCT、CRP显著低于对照组，差异有统计学意义；②治疗前，2组患者体温（T ）、呼吸频率（RR）、心率（HR）、收缩压（SBP）、舒张压（DBP）相比，差异无统计学意义（P＞0．05）。治疗7 d后，观察组T、RR、HR显著低于对照组，SBP、DBP显著高于对照组，差异有统计学意义；③观察组ICU住院时间、多器官功能障碍综合征（MODS）发生率、病死率显著低于对照组，差异有统计学意义。结论乌司他丁治疗脓毒症休克的疗效确切，可以抑制炎症反应，改善微循环、改善组织灌注，改善患者的预后。
目的：探討烏司他丁對膿毒癥休剋患者血常規、血乳痠（L A ）及降鈣素原（PC T ）的影響。方法根據隨機數字錶法將2011年3月～2014年10月我院收治的130例膿毒癥休剋患者分為對照組（65例）與觀察組（65例），對照組接受膿毒癥休剋的常規治療，觀察組在常規治療基礎上聯閤使用烏司他丁，對比分析2組患者的治療效果。結果①治療前，2組患者白細胞計數（WBC）、中性粒細胞計數（NEU＃）、中性粒細胞比值（NEU％）、LA、PCT、C反應蛋白（CRP）相比，差異無統計學意義。治療7 d後，觀察組WBC、NEU＃、NEU％、LA、PCT、CRP顯著低于對照組，差異有統計學意義；②治療前，2組患者體溫（T ）、呼吸頻率（RR）、心率（HR）、收縮壓（SBP）、舒張壓（DBP）相比，差異無統計學意義（P＞0．05）。治療7 d後，觀察組T、RR、HR顯著低于對照組，SBP、DBP顯著高于對照組，差異有統計學意義；③觀察組ICU住院時間、多器官功能障礙綜閤徵（MODS）髮生率、病死率顯著低于對照組，差異有統計學意義。結論烏司他丁治療膿毒癥休剋的療效確切，可以抑製炎癥反應，改善微循環、改善組織灌註，改善患者的預後。
목적：탐토오사타정대농독증휴극환자혈상규、혈유산（L A ）급강개소원（PC T ）적영향。방법근거수궤수자표법장2011년3월～2014년10월아원수치적130례농독증휴극환자분위대조조（65례）여관찰조（65례），대조조접수농독증휴극적상규치료，관찰조재상규치료기출상연합사용오사타정，대비분석2조환자적치료효과。결과①치료전，2조환자백세포계수（WBC）、중성립세포계수（NEU＃）、중성립세포비치（NEU％）、LA、PCT、C반응단백（CRP）상비，차이무통계학의의。치료7 d후，관찰조WBC、NEU＃、NEU％、LA、PCT、CRP현저저우대조조，차이유통계학의의；②치료전，2조환자체온（T ）、호흡빈솔（RR）、심솔（HR）、수축압（SBP）、서장압（DBP）상비，차이무통계학의의（P＞0．05）。치료7 d후，관찰조T、RR、HR현저저우대조조，SBP、DBP현저고우대조조，차이유통계학의의；③관찰조ICU주원시간、다기관공능장애종합정（MODS）발생솔、병사솔현저저우대조조，차이유통계학의의。결론오사타정치료농독증휴극적료효학절，가이억제염증반응，개선미순배、개선조직관주，개선환자적예후。
Objective To discuss the effect of ulinastatin on blood routine ,lactic acid(LA) and procalcitonin in patients with sepsis shock .Methods According to the random number table method ,130 cases of patients with septic shock from March 2011 to Octo‐ber 2014 in our hospital were divided into control group (65 cases) and observation group (65 cases) .The control group received routine treatment of septic shock ,and the observation group were treated on the basis of the conventional treatment combined use of ulinastatin .Treatment effect of patients of the 2 groups were compared and analyzed .Results ①Leukocyte count (WBC) ,neu‐trophil count (NEU# ) ,the ratio of neutrophils (NEU% ) ,LA ,PCT ,C reactive protein (CRP) of the 2 groups patients before treatment showed no significant difference .After 7 days treatment ,WBC ,NEU# ,NEU% ,LA ,PCT ,CRP of the observation group were significantly lower than those of the control group .The difference was statistically significant ;②Before treatment ,the body temperature (T) ,respiratory rate (RR) ,heart rate (HR) ,systolic blood pressure (SBP) ,and diastolic blood pressure (DBP) of the 2 groups patients were compared .There was no significant difference .After 7 days treatment ,T ,RR ,and HR of the observation group were significantly lower than those of the control group .SBP and DBP were significantly higher than those of the control group .The difference was statistically significant ;③ICU hospitalization time ,and multiple organ dysfunction syndrome (MODS) and incidence mortality was significantly lower than those of the control group ,the difference was statistically signifi‐cant .Conclusion The effect of ulinastatin in the treatment of septic shock is exact .Ulinastain can inhibit inflammatory reaction , and improve microcirculation ,tissue perfusion ,and the prognosis of patients .
