CAJ | 학술논문

目的：评价 A 型肉毒毒素（BTX －A）治疗原发性难治性三叉神经痛的疗效。方法选取54例原发性难治性三叉神经痛患者，应用 A 型肉毒毒素在疼痛部位及板机点局部多点皮下注射治疗，用药前及用药后2周、2个月、6个月应用疼痛视觉模拟评分（VAS）进行疗效分析。结果患者治疗前、治疗后2周、2个月及6个月疼痛 VAS 得分分别为（10．2±1．3）分、（3．6±2．3）分、（2．8±2．2）分及（4．8±3．1）分，差异有统计学意义（P ＜0．001）。用药后2周、2个月、6个月的总有效率分别为87．03％、72．22％、61．11％，组间两两比较，差异有统计学意义（P ＜0．05）。无严重并发症。结论A 型肉毒毒素治疗原发性难治性三叉神经痛临床疗效显著。
목적：평개 A 형육독독소（BTX －A）치료원발성난치성삼차신경통적료효。방법선취54례원발성난치성삼차신경통환자，응용 A 형육독독소재동통부위급판궤점국부다점피하주사치료，용약전급용약후2주、2개월、6개월응용동통시각모의평분（VAS）진행료효분석。결과환자치료전、치료후2주、2개월급6개월동통 VAS 득분분별위（10．2±1．3）분、（3．6±2．3）분、（2．8±2．2）분급（4．8±3．1）분，차이유통계학의의（P ＜0．001）。용약후2주、2개월、6개월적총유효솔분별위87．03％、72．22％、61．11％，조간량량비교，차이유통계학의의（P ＜0．05）。무엄중병발증。결론A 형육독독소치료원발성난치성삼차신경통림상료효현저。
Objective To investigate the efficacy of botulinum toxin type A(BTX -A)in the treatment of primary intractable trigeminal neuralgia.Methods 54 patients with primary intractable trigeminal neuralgia were selected and treated with multi -point subcutaneous injection of BTX -A in the painful area and the trigger point.The efficacy was assessed by visual analog scores(VAS)before and 2 weeks,2 month and 6 months after the treatment.Results The VAS before and 2 weeks,2 months and 6 months after the treatment were (10.2 ±1.3),(3.6 ±2.3),(2.8 ±2.2)and(4.8 ±3.1)scores respectively,and the differences were statistically significant(P <0.05).The effective rates at 2 weeks,2 months and 6 months after the treatment were 87.03%、72.22% and 61.11% respectively,and the differences were statistically significant(P <0.05).No severe com-plication was found.Conclusion BTX -A has a significant clinical effect on primary intractable trigeminal neuralgia. <br> and 6 months after the treatment were (10.2 ±1.3),(3.6 ±2.3),(2.8 ±2.2)and(4.8 ±3.1)scores respectively,and the differences were statistically significant(P <0.05).The effective rates at 2 weeks,2 months and 6 months after the treatment were 87.03%、72.22% and 61.11% respectively,and the differences were statistically significant(P <0.05).No severe com-plication was found.Conclusion BTX -A has a significant clinical effect on primary intractable trigeminal neuralgia.