CAJ | 학술논문

目的：探讨脑干听觉诱发电位( BAEP)在新生儿核黄疸的变化,为新生儿核黄疸的早期诊断提供依据。方法68例核黄疸患儿,按照有无神经系统疾病分为两组,胆红素脑病组38例,胆红素非脑病组30例。两组均进行BAEP检测,对异常者进行随访复查。结果脑病组患儿中BAEP正常13例,异常25例,其中13例为重度,8例中度,4例轻度。非脑病组患儿中,BAEP正常21例,异常9例,其中2例为重度,2例为中度,5例轻度。随访显示,首次BAEP异常的34例中,25例转正常,6例持续异常伴有后遗症,3例失访。经治疗后两组黄疸消退后BAEP均有好转,表现为各波潜伏期均较前缩短(P<0．05),两组BAEP与较治疗前相比,差异均有统计学意义(P<0．05)。结论 BAEP异常是新生儿核黄疸的重要特征,黄疸患儿血清总胆红素>221μmol/L时,可出现神经系统受损,BAEP显示异常。
목적：탐토뇌간은각유발전위( BAEP)재신생인핵황달적변화,위신생인핵황달적조기진단제공의거。방법68례핵황달환인,안조유무신경계통질병분위량조,담홍소뇌병조38례,담홍소비뇌병조30례。량조균진행BAEP검측,대이상자진행수방복사。결과뇌병조환인중BAEP정상13례,이상25례,기중13례위중도,8례중도,4례경도。비뇌병조환인중,BAEP정상21례,이상9례,기중2례위중도,2례위중도,5례경도。수방현시,수차BAEP이상적34례중,25례전정상,6례지속이상반유후유증,3례실방。경치료후량조황달소퇴후BAEP균유호전,표현위각파잠복기균교전축단(P<0．05),량조BAEP여교치료전상비,차이균유통계학의의(P<0．05)。결론 BAEP이상시신생인핵황달적중요특정,황달환인혈청총담홍소>221μmol/L시,가출현신경계통수손,BAEP현시이상。
Objective To explore the relationship between the changes of BAEP and kernicterus in neonates, in order to provide evi-dence for the diagnoses of it. Methods Sixty-eight hospitalized patients with neonatal jaundice were divided into two groups:38 neonates with bilirubin encephalopathy and 30 cases with bilirubin non-encephalopathy. All cases received initial BAEP within 24 hours of hospitaliza-tion. Then all abnormal cases were followed till one year old. Results 13 cases in neonates with encephalopathy group showed normal BAEP and 25 cases were abnormal with 13 severe cases, 8 moderate cases and 4 mild cases;21 cases in neonates with non-encephalopathy group showed normal BAEP and 9 cases were abnormal with 2 severe cases, 2 moderate cases and 5 mild cases. It showed that 34 cases had abnor-mal BAEP for the first time in follow-up with 25 turning to normal cases, 6 cases with clinic sequelae, and 3 cases lost following. When after treatment of jaundice, the abnormalities on initial BAER came back to normal in some cases, the difference being very significant ( P <0. 05). The incidence of BAEP had significant difference between prior to treatment and after treatment when jaundice come down(P<0. 05) in both groups. Conclusion Abnormal BAEP is an important character of neonatal kernicterus. When TSB>221 μmol/L, the nervous sys-tem can be damaged and BAEP is influenced.