中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
Chinese Journal of Experimental and Clinical Virology
2015年
4期
322-325
,共4页
刘启材%林思炜%蔡卫平%何浩岚%张坚生%易俊卿%廖宝林
劉啟材%林思煒%蔡衛平%何浩嵐%張堅生%易俊卿%廖寶林
류계재%림사위%채위평%하호람%장견생%역준경%료보림
肝炎病毒,乙型%儿童保健服务%组织学,比较
肝炎病毒,乙型%兒童保健服務%組織學,比較
간염병독,을형%인동보건복무%조직학,비교
Hepatitis B virus%Child health services%Histology,comparative
目的 探讨儿童慢性乙型肝炎(CHB)患者肝组织病理变化特征.方法 回顾性收集伴有肝活检儿童CHB患者资料,分析其肝组织病理变化特征及其实验室预测指标.结果 共124例儿童CHB纳入本项研究,其中HBeAg阳性114例(91.9％)、HBeAg阴性10例(8.1％).HBeAg阳性儿童CHB组中,不同ALT水平显著性肝脏炎症发生率ALT≤正常值上限(ULN)组32.1％ (9/28)、ALT(1 ～2)×ULN组60.7％ (17/28)与ALT＞2×ULN组81.0％ (47/58),显著性肝纤维化发生率为ALT≤ULN组46.4％(13/28)、ALT (1～2) ×ULN组71.4％ (20/28)与ALT＞2×ULN组74.1％ (43/58).ALT(1 ～2)×ULN组与ALT＞2 × ULN组的显著性肝组织异常发生率较ALT≤ULN组明显升高.Logistic回归分析显示仅AST水平与显著性肝脏炎症(OR=1.032,P=0.008)与显著性肝纤维化(OR=1.026,P=0.007)相关.结论 儿童CHB中显著性肝脏组织学异常发生率较高,AST水平可反映病理变化程度.
目的 探討兒童慢性乙型肝炎(CHB)患者肝組織病理變化特徵.方法 迴顧性收集伴有肝活檢兒童CHB患者資料,分析其肝組織病理變化特徵及其實驗室預測指標.結果 共124例兒童CHB納入本項研究,其中HBeAg暘性114例(91.9％)、HBeAg陰性10例(8.1％).HBeAg暘性兒童CHB組中,不同ALT水平顯著性肝髒炎癥髮生率ALT≤正常值上限(ULN)組32.1％ (9/28)、ALT(1 ～2)×ULN組60.7％ (17/28)與ALT＞2×ULN組81.0％ (47/58),顯著性肝纖維化髮生率為ALT≤ULN組46.4％(13/28)、ALT (1～2) ×ULN組71.4％ (20/28)與ALT＞2×ULN組74.1％ (43/58).ALT(1 ～2)×ULN組與ALT＞2 × ULN組的顯著性肝組織異常髮生率較ALT≤ULN組明顯升高.Logistic迴歸分析顯示僅AST水平與顯著性肝髒炎癥(OR=1.032,P=0.008)與顯著性肝纖維化(OR=1.026,P=0.007)相關.結論 兒童CHB中顯著性肝髒組織學異常髮生率較高,AST水平可反映病理變化程度.
목적 탐토인동만성을형간염(CHB)환자간조직병리변화특정.방법 회고성수집반유간활검인동CHB환자자료,분석기간조직병리변화특정급기실험실예측지표.결과 공124례인동CHB납입본항연구,기중HBeAg양성114례(91.9％)、HBeAg음성10례(8.1％).HBeAg양성인동CHB조중,불동ALT수평현저성간장염증발생솔ALT≤정상치상한(ULN)조32.1％ (9/28)、ALT(1 ～2)×ULN조60.7％ (17/28)여ALT＞2×ULN조81.0％ (47/58),현저성간섬유화발생솔위ALT≤ULN조46.4％(13/28)、ALT (1～2) ×ULN조71.4％ (20/28)여ALT＞2×ULN조74.1％ (43/58).ALT(1 ～2)×ULN조여ALT＞2 × ULN조적현저성간조직이상발생솔교ALT≤ULN조명현승고.Logistic회귀분석현시부AST수평여현저성간장염증(OR=1.032,P=0.008)여현저성간섬유화(OR=1.026,P=0.007)상관.결론 인동CHB중현저성간장조직학이상발생솔교고,AST수평가반영병리변화정도.
Objective To investigate the liver histological characteristics of children with chronic hepatitis B (CHB).Methods We recruited data of children with CHB and liver biopsy,then analyzed their liver histopathological characteristics and their associations with laboratory parameters.Results One hundred and twenty-four children with CHB were included in the present study,including 114 (91.9％) HBeAg-positive CHB children and 10 (8.1％) HBeAg-negative CHB children.In HBeAg-positive CHB children,the frequency of significant necroinflammation stratified by ALT levels was 32.1％ (9/28) in ALT ≤ULN,60.7％ (17/28) in ALT(1-2) ×ULN and 81.0％ (47/58) in ALT＞2 ×ULN group,while significant fibrosis was 46.4％ (13/28) in ALT ≤ ULN,71.4％ (20/28) in ALT (1-2) × ULN and 74.1％ (43/58) in ALT ＞ 2 × ULN group,respectively.Significant liver histological abnormalities were much higher in the ALT ＞ 2 × ULN and ALT (1-2) × ULN groups than the ALT ≤ ULN group.Logistic analysis indicated only AST levels associated with significant inflammation (OR =1.032,P =0.008) and significant fibrosis (OR =1.026,P =0.007).Conclusion Frequencies of significant liver histological abnormalities in children with CHB are high,and AST levels are associated with them.
