中国医药导报
中國醫藥導報
중국의약도보
China Medical Herald
2015年
26期
8-11
,共4页
糖尿病视网膜病变%补体C1q肿瘤坏死因子相关蛋白3%补体C1q肿瘤坏死因子相关蛋白9
糖尿病視網膜病變%補體C1q腫瘤壞死因子相關蛋白3%補體C1q腫瘤壞死因子相關蛋白9
당뇨병시망막병변%보체C1q종류배사인자상관단백3%보체C1q종류배사인자상관단백9
Diabetic retinopathy%CTRP3%CTRP9
目的：探讨血清补体C1q肿瘤坏死因子相关蛋白(CTRP)3、CTRP9水平对糖尿病视网膜病变(DR)患者的影响及相关性。方法选取2014年3月~2015年3月在西安市第四医院眼科及内分泌科住院的DR患者60例为DR组,同时选取50例无DR的2型糖尿病患者为单纯糖尿病组和50例健康体检者为正常对照组。采集基本资料,抽空腹血行CTRP3、CTRP9、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及糖化血红蛋白(HbA1c)等检查,并进行组间比较。采用Pearson相关分析进行DR患者CTRP3、CTRP9的相关性检验,采用Logistic回归分析探讨DR的影响因素。结果单纯糖尿病组和DR组的FBG、HbA1c、TG、TC、LDL-C水平均高于正常对照组,HLD-C、CTRP3、CTRP9水平均低于正常对照组,差异有统计学意义(P<0.05)；DR组的病程长于单纯糖尿病组,FBG、HbA1c、TC、LDL-C水平均高于单纯糖尿病组,CTRP3、CTRP9水平均低于单纯糖尿病组,差异有统计学意义(P<0.05)。 Pearson相关分析显示,DR患者CTRP3与CTRP9水平呈正相关关系(r=0.743,P<0.05)。多因素Logistic回归分析显示,CTRP3和CTRP9与DR相关,随着CTRP3和CTEP9水平降低,DR的患病风险显著增加(P<0.05)。结论 CTRP3和CTRP9与DR发生、发展相关,其水平降低可能导致DR的发生。
目的：探討血清補體C1q腫瘤壞死因子相關蛋白(CTRP)3、CTRP9水平對糖尿病視網膜病變(DR)患者的影響及相關性。方法選取2014年3月~2015年3月在西安市第四醫院眼科及內分泌科住院的DR患者60例為DR組,同時選取50例無DR的2型糖尿病患者為單純糖尿病組和50例健康體檢者為正常對照組。採集基本資料,抽空腹血行CTRP3、CTRP9、空腹血糖(FBG)、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)及糖化血紅蛋白(HbA1c)等檢查,併進行組間比較。採用Pearson相關分析進行DR患者CTRP3、CTRP9的相關性檢驗,採用Logistic迴歸分析探討DR的影響因素。結果單純糖尿病組和DR組的FBG、HbA1c、TG、TC、LDL-C水平均高于正常對照組,HLD-C、CTRP3、CTRP9水平均低于正常對照組,差異有統計學意義(P<0.05)；DR組的病程長于單純糖尿病組,FBG、HbA1c、TC、LDL-C水平均高于單純糖尿病組,CTRP3、CTRP9水平均低于單純糖尿病組,差異有統計學意義(P<0.05)。 Pearson相關分析顯示,DR患者CTRP3與CTRP9水平呈正相關關繫(r=0.743,P<0.05)。多因素Logistic迴歸分析顯示,CTRP3和CTRP9與DR相關,隨著CTRP3和CTEP9水平降低,DR的患病風險顯著增加(P<0.05)。結論 CTRP3和CTRP9與DR髮生、髮展相關,其水平降低可能導緻DR的髮生。
목적：탐토혈청보체C1q종류배사인자상관단백(CTRP)3、CTRP9수평대당뇨병시망막병변(DR)환자적영향급상관성。방법선취2014년3월~2015년3월재서안시제사의원안과급내분비과주원적DR환자60례위DR조,동시선취50례무DR적2형당뇨병환자위단순당뇨병조화50례건강체검자위정상대조조。채집기본자료,추공복혈행CTRP3、CTRP9、공복혈당(FBG)、총담고순(TC)、삼선감유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)급당화혈홍단백(HbA1c)등검사,병진행조간비교。채용Pearson상관분석진행DR환자CTRP3、CTRP9적상관성검험,채용Logistic회귀분석탐토DR적영향인소。결과단순당뇨병조화DR조적FBG、HbA1c、TG、TC、LDL-C수평균고우정상대조조,HLD-C、CTRP3、CTRP9수평균저우정상대조조,차이유통계학의의(P<0.05)；DR조적병정장우단순당뇨병조,FBG、HbA1c、TC、LDL-C수평균고우단순당뇨병조,CTRP3、CTRP9수평균저우단순당뇨병조,차이유통계학의의(P<0.05)。 Pearson상관분석현시,DR환자CTRP3여CTRP9수평정정상관관계(r=0.743,P<0.05)。다인소Logistic회귀분석현시,CTRP3화CTRP9여DR상관,수착CTRP3화CTEP9수평강저,DR적환병풍험현저증가(P<0.05)。결론 CTRP3화CTRP9여DR발생、발전상관,기수평강저가능도치DR적발생。
Objective To discuss influence of serum C1q tumor necrosis factor related protein (CTRP)3, CTRP9 on pa-tients with diabetic retinopathy (DR) and its relationship. Methods 60 patients with DR in Ophthalmology and En-docrinology Department of the Fourth Hospital of Xi’an City during March 2014 and March 2015 were selected as DR group, while another 50 diabetic patients without DR were selected as simple diabetic group and 50 healthy volunteers were matched as normal control group. Demographic data and disease history were gained. Fasting blood sample was collected for detection of CTRP3, CTRP9, FBG, TC, TG, HDL-C, LDL-C and HbA1c. Pearson analysis was used to ana-lyze the relationship of CTRP3 and CTRP9 in DR patients. Logistic regression analysis was used to discuss the influ-ence factor of DR. Results FBG, HbA1c, TG, TC, LDL-C level of simple diabetic group and DR group were higher than those of normal control group, HLD-C, CTRP3, CTRP9 level of simple diabetic group and DR group were lower than those of normal control group, with statistical differences (P<0.05). Course of disease in DR group was longer than that in simple diabetic group, FBG, HbA1c, TC, LDL-C level in DR group were higher than those in simple diabetic group, CTRP3, CTRP9 level in DR group were lower than those in simple diabetic group, with statistical differences (P<0.05). Pearson analysis showed that CTRP3 and CTRP9 level of DR patients was positively correlated (r=0.743, P<0.05). Mul-ti-factor Logistic analysis showed that CTRP3 and CTRP9 were independent related with the development of DR. The risk of DR increased significantly with the reduced CTRP3 and CTRP9 level (P < 0.05). Conclusion CTRP3 and CTRP9 are related to the occurrence and development of DR. Its lower level may lead to the occurrence of DR.
