中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
Chinese Journal of Experimental and Clinical Virology
2015年
4期
348-350
,共3页
何鑫%陶绘丞%王淑珍%翟妍%张震宇%刁小莉
何鑫%陶繪丞%王淑珍%翟妍%張震宇%刁小莉
하흠%도회승%왕숙진%적연%장진우%조소리
卵巢肿瘤%细胞因子类%髓性分化因子88
卵巢腫瘤%細胞因子類%髓性分化因子88
란소종류%세포인자류%수성분화인자88
Ovarian neoplasms%Cyeokines%MyD88
目的 探讨髓性分化因子88(MyD88)在卵巢癌组织中的表达及其临床意义.方法 收集2000年8月至2010年2月在本院接受首次手术治疗的115例卵巢癌患者的肿瘤标本及癌旁正常卵巢组织标本,所有患者的诊断均经术后病理学检测结果证实,采用免疫组织化学方法检测MyD88蛋白在卵巢癌及癌旁正常组织中的表达,并探讨MyD88的表达量与卵巢癌患者临床病理特征和预后的相关性.结果 卵巢癌肿瘤组织标本中MyD88的阳性表达率为70.4％,卵巢癌旁正常组织中的阳性表达率为23.5％,两者相比差异有统计学意义(P＜0.05);此外,MyD88的阳性表达量与卵巢癌患者的年龄、肿瘤大小、组织学类型、有无腹水和病理学分级无关(P＞0.05),而与患者的有无淋巴结转移及临床分期相关(P＜0.05);MyD88阳性表达的卵巢癌患者五年生存率显著低于阴性表达的卵巢癌患者(P ＜0.001).结论 MyD88在卵巢癌组织中的表达显著升高,其可能在卵巢癌的发生、发展和侵袭中发挥重要作用.
目的 探討髓性分化因子88(MyD88)在卵巢癌組織中的錶達及其臨床意義.方法 收集2000年8月至2010年2月在本院接受首次手術治療的115例卵巢癌患者的腫瘤標本及癌徬正常卵巢組織標本,所有患者的診斷均經術後病理學檢測結果證實,採用免疫組織化學方法檢測MyD88蛋白在卵巢癌及癌徬正常組織中的錶達,併探討MyD88的錶達量與卵巢癌患者臨床病理特徵和預後的相關性.結果 卵巢癌腫瘤組織標本中MyD88的暘性錶達率為70.4％,卵巢癌徬正常組織中的暘性錶達率為23.5％,兩者相比差異有統計學意義(P＜0.05);此外,MyD88的暘性錶達量與卵巢癌患者的年齡、腫瘤大小、組織學類型、有無腹水和病理學分級無關(P＞0.05),而與患者的有無淋巴結轉移及臨床分期相關(P＜0.05);MyD88暘性錶達的卵巢癌患者五年生存率顯著低于陰性錶達的卵巢癌患者(P ＜0.001).結論 MyD88在卵巢癌組織中的錶達顯著升高,其可能在卵巢癌的髮生、髮展和侵襲中髮揮重要作用.
목적 탐토수성분화인자88(MyD88)재란소암조직중적표체급기림상의의.방법 수집2000년8월지2010년2월재본원접수수차수술치료적115례란소암환자적종류표본급암방정상란소조직표본,소유환자적진단균경술후병이학검측결과증실,채용면역조직화학방법검측MyD88단백재란소암급암방정상조직중적표체,병탐토MyD88적표체량여란소암환자림상병리특정화예후적상관성.결과 란소암종류조직표본중MyD88적양성표체솔위70.4％,란소암방정상조직중적양성표체솔위23.5％,량자상비차이유통계학의의(P＜0.05);차외,MyD88적양성표체량여란소암환자적년령、종류대소、조직학류형、유무복수화병이학분급무관(P＞0.05),이여환자적유무림파결전이급림상분기상관(P＜0.05);MyD88양성표체적란소암환자오년생존솔현저저우음성표체적란소암환자(P ＜0.001).결론 MyD88재란소암조직중적표체현저승고,기가능재란소암적발생、발전화침습중발휘중요작용.
Objective To examine the expression and clinical significance of MyD88 in ovarian carcinomas.Methods Specimens from 115 patients with ovarian carcinomas managed in our hospital between Augest 2000 and February 2010 were included in this study.Immunohistochemical staining was used to detect the expression of MyD88 in ovarian carcinomas and normal tissues.All the specimens were confirmed by pathology for ovarian carcinomas and normal tissues by HE staining.The correlation between the expression and clinical significance of patients was analyzed.Results The positive expression rate of MyD88 in ovarian carcinomas and normal tissues was 70.4％ and 23.5％,respectively.MyD88 expression was significantly associated with tumor stage and distant metastasis (P ＜ 0.05).According to the survival analysis of 115 ovarian carcinomas patients,cases in the MyD88 positive-expression group showed poorer overall survival rate when compared with negative-expression group (P ＜ 0.001).Conclusion These results indicate that the expression of MyD88 was related with in the progression of ovarian carcinomas and may have clinical utility in the prediction of prognosis of ovarian carcinomas.
