CAJ | 학술논문

目的：了解某院大肠埃希菌的分布特点及其耐药性，指导临床合理应用抗菌药物。方法对766株大肠埃希菌的分布及耐药率进行回顾性分析。采用法国生物梅里埃公司全自动细菌鉴定仪 VITEK2 compact进行菌株鉴定，采用K-B法进行药敏试验，按美国临床实验室标准化委员会2014年标准判读结果。结果766株大肠埃希菌主要分离自尿液和痰液标本，分别占52．87%和13．84%；其中鉴定出产超广谱β-内酰胺酶( ESBLs)大肠埃希菌366株，占大肠埃希菌总数的47．78%。产ESBLs大肠埃希菌对常用抗菌药物的耐药率明显高于非产ESBLs大肠埃希菌(P<0．05)。结论大肠埃希菌是泌尿道和呼吸道感染的常见病原菌，产ESBLs大肠埃希菌的耐药率高，临床上应根据药敏合理使用抗菌药物。
목적：료해모원대장애희균적분포특점급기내약성，지도림상합리응용항균약물。방법대766주대장애희균적분포급내약솔진행회고성분석。채용법국생물매리애공사전자동세균감정의 VITEK2 compact진행균주감정，채용K-B법진행약민시험，안미국림상실험실표준화위원회2014년표준판독결과。결과766주대장애희균주요분리자뇨액화담액표본，분별점52．87%화13．84%；기중감정출산초엄보β-내선알매( ESBLs)대장애희균366주，점대장애희균총수적47．78%。산ESBLs대장애희균대상용항균약물적내약솔명현고우비산ESBLs대장애희균(P<0．05)。결론대장애희균시비뇨도화호흡도감염적상견병원균，산ESBLs대장애희균적내약솔고，림상상응근거약민합리사용항균약물。
Objective To study the distribution and its drug resistance of Escherichia coli in a hospital in order to introduce a rea-sonable clinical use of antibiotics. Methods We retrospectively analyzed the distribution and drug resistance rates of 766 strains of clinical Escherichia coli collected in the hospital, made the bacteria identifications by BioMerieux automatic bacteria identification analyzer( VITEK2 compact) and adopted Kirby-Bauer method for the drug-sensitivity tests. The results were determined according to the standard of Clinical and Laboratory Standards Institute (CLSI) issued in 2014. Results It was found that 766 strains of Escherichia coli were mainly isolated from u-rine (52. 87%) and sputum (13. 84%) specimens. There were 366 strains (47. 78%) of Escherichia coli producing extended-spectrumβ-lactamases ( ESBLs) . The drug resistance rates of Escherichia coli result in ESBLs to the common antibiotics were significantly higher than those of the non-ESBLs-producing Escherichia coli (P<0. 05). Conclusion Escherichia coli is a type of common pathogen leading to uri-nary tract and respiratory tract infections. It is necessary to strengthen the reasonable clinical use of antibiotics in accordance with susceptibil-ity testing because of the higher drug resistance rate of the ESBLs-producing Escherichia coli.