中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
Chinese Journal of Experimental and Clinical Virology
2015年
4期
313-315
,共3页
邹容容%张国良%刘映霞%林益敏%袁静%李建明%王艳荣%邓永%曾文
鄒容容%張國良%劉映霞%林益敏%袁靜%李建明%王豔榮%鄧永%曾文
추용용%장국량%류영하%림익민%원정%리건명%왕염영%산영%증문
白细胞介素1%多态性,单核苷酸%手足口病
白細胞介素1%多態性,單覈苷痠%手足口病
백세포개소1%다태성,단핵감산%수족구병
Interleukin-1%Polymorphism,single nucleotide%Hand-foot and mouth disease
目的 探讨IL1B基因-31位点单核苷酸多态性(SNP)与EV71手足口病(HFMD)易感性及临床表型的相关性.方法 采用病例-对照研究方法,应用TaqMan探针基因分型技术,对1196例EV71 HFMD[(其中801例为轻症(M-EV71),395例为重症(S-EV71)]和573例健康对照人群(HC)IL1B基因-31位点进行分型,比较两组人群等位基因频率差异.(1)探讨IL1B基因-31位点SNP与EV71 HFMD易感性的相关性;(2)探讨在不同性别中-31位点SNP与EV71 HFMD易感性的相关性;(3)探讨-31位点SNP与EV71 HFMD临床表型的相关性.结果 (1) EV71 HFMD患者中IL1B基因-31 T等位基因的频率明显高于HC,这提示T等位基因增加了患EV71 HFMD的风险(OR=1.22;95％ CI,1.06 ～1.40;P =0.007);(2)男性EV71 HFMD患者中IL1B基因-31 T等位基因的频率明显高于男性HC,这提示T等位基因也增加了男性患EV71 HFMD的风险(OR=1.24;95％ CI,1.03 ～1.48;P =0.022);(3)IL1B基因-31位点SNP与EV71 HFMD的严重程度无相关性.结论 IL1B基因-31 T等位基因与EV71 HFMD易感性相关,而与EV71 HFMD严重程度无相关性;IL1B基因-31 T等位基因与男性EV71 HFMD的易感性也具有相关性.
目的 探討IL1B基因-31位點單覈苷痠多態性(SNP)與EV71手足口病(HFMD)易感性及臨床錶型的相關性.方法 採用病例-對照研究方法,應用TaqMan探針基因分型技術,對1196例EV71 HFMD[(其中801例為輕癥(M-EV71),395例為重癥(S-EV71)]和573例健康對照人群(HC)IL1B基因-31位點進行分型,比較兩組人群等位基因頻率差異.(1)探討IL1B基因-31位點SNP與EV71 HFMD易感性的相關性;(2)探討在不同性彆中-31位點SNP與EV71 HFMD易感性的相關性;(3)探討-31位點SNP與EV71 HFMD臨床錶型的相關性.結果 (1) EV71 HFMD患者中IL1B基因-31 T等位基因的頻率明顯高于HC,這提示T等位基因增加瞭患EV71 HFMD的風險(OR=1.22;95％ CI,1.06 ～1.40;P =0.007);(2)男性EV71 HFMD患者中IL1B基因-31 T等位基因的頻率明顯高于男性HC,這提示T等位基因也增加瞭男性患EV71 HFMD的風險(OR=1.24;95％ CI,1.03 ～1.48;P =0.022);(3)IL1B基因-31位點SNP與EV71 HFMD的嚴重程度無相關性.結論 IL1B基因-31 T等位基因與EV71 HFMD易感性相關,而與EV71 HFMD嚴重程度無相關性;IL1B基因-31 T等位基因與男性EV71 HFMD的易感性也具有相關性.
목적 탐토IL1B기인-31위점단핵감산다태성(SNP)여EV71수족구병(HFMD)역감성급림상표형적상관성.방법 채용병례-대조연구방법,응용TaqMan탐침기인분형기술,대1196례EV71 HFMD[(기중801례위경증(M-EV71),395례위중증(S-EV71)]화573례건강대조인군(HC)IL1B기인-31위점진행분형,비교량조인군등위기인빈솔차이.(1)탐토IL1B기인-31위점SNP여EV71 HFMD역감성적상관성;(2)탐토재불동성별중-31위점SNP여EV71 HFMD역감성적상관성;(3)탐토-31위점SNP여EV71 HFMD림상표형적상관성.결과 (1) EV71 HFMD환자중IL1B기인-31 T등위기인적빈솔명현고우HC,저제시T등위기인증가료환EV71 HFMD적풍험(OR=1.22;95％ CI,1.06 ～1.40;P =0.007);(2)남성EV71 HFMD환자중IL1B기인-31 T등위기인적빈솔명현고우남성HC,저제시T등위기인야증가료남성환EV71 HFMD적풍험(OR=1.24;95％ CI,1.03 ～1.48;P =0.022);(3)IL1B기인-31위점SNP여EV71 HFMD적엄중정도무상관성.결론 IL1B기인-31 T등위기인여EV71 HFMD역감성상관,이여EV71 HFMD엄중정도무상관성;IL1B기인-31 T등위기인여남성EV71 HFMD적역감성야구유상관성.
Objective To explore the association between IL-1B gene-31 single nucleotide polymorphisms(SNP)and susceptibility and severity of EV71 HFMD.Methods The genotype of IL-1B gene-31 SNP was determined in EV71 HFMD(n =1196,including 801 mild cases,395 severe cases)and healthy control group (HC,n =573)with TaqMan assay in a case-control study.(1)To explore the association between-31 SNP and susceptibility to EV71 HFMD;(2)To explore the association between-31 SNP and susceptibility to EV71 HFMD in different sex population;(3)To explored the association between-31 SNP and severity to EV71 HFMD.Results (1)IL-1B gene-31 T allele frequency was significantly higher in EV71 HFMD than that in HC.(2)IL-1B gene-31 T allele frequency was significantly higher in EV71 HFMD than in HC for male population.(3)The IL-1B gene-31 T is not associated with the severity of EV71 HFMD.Conclusion The IL-1B gene-31 T allele was associated with susceptibility to EV71 HFMD,but was not associated with the severity of EV71 HFMD,especially,the IL-1B gene-31 T allele was associated with susceptibility to EV71 HFMD for male population.
