CAJ | 학술논문

目的：探讨大株红景天注射液对原发性高血压患者血清高敏C-反应蛋白（hs-CRP）、颈动脉粥样硬化程度的影响和意义。方法选取我院2012年4月～2014年10月收治的原发性高血压患者134例作为研究对象，随机分为红景天组66例和对照组68例。两组均给予常规降压治疗，红景天组在此基础上给予大株红景天注射液10 ml/d，连续2周。观察治疗前后血清hs-CRP、颈动脉内膜中层厚度（IMT）水平的变化。结果红景天组治疗后IMT、hs-CRP显著下降，与治疗前比较，差异有统计学意义（P＜0.05）；对照组治疗后血清hs-CRP显著下降，差异有统计学意义（P＜0.05），IMT下降不明显，差异无统计学意义（P＞0.05）。治疗2周后，红景天组与对照组血清hs-CRP比较，差异有统计学意义（P＜0.05）；红景天组与对照组IMT比较，差异无统计学意义（P＞0.05），但有降低的趋势。结论大株红景天注射液能使原发性高血压患者的血清hs-CRP更快恢复至正常水平，明显减低IMT，其机制可能与阻断动脉粥样硬化炎症反应过程有关。
목적：탐토대주홍경천주사액대원발성고혈압환자혈청고민C-반응단백（hs-CRP）、경동맥죽양경화정도적영향화의의。방법선취아원2012년4월～2014년10월수치적원발성고혈압환자134례작위연구대상，수궤분위홍경천조66례화대조조68례。량조균급여상규강압치료，홍경천조재차기출상급여대주홍경천주사액10 ml/d，련속2주。관찰치료전후혈청hs-CRP、경동맥내막중층후도（IMT）수평적변화。결과홍경천조치료후IMT、hs-CRP현저하강，여치료전비교，차이유통계학의의（P＜0.05）；대조조치료후혈청hs-CRP현저하강，차이유통계학의의（P＜0.05），IMT하강불명현，차이무통계학의의（P＞0.05）。치료2주후，홍경천조여대조조혈청hs-CRP비교，차이유통계학의의（P＜0.05）；홍경천조여대조조IMT비교，차이무통계학의의（P＞0.05），단유강저적추세。결론대주홍경천주사액능사원발성고혈압환자적혈청hs-CRP경쾌회복지정상수평，명현감저IMT，기궤제가능여조단동맥죽양경화염증반응과정유관。
Objective To explore the influence and signiifcance of serum hs-CRP and AS of patients with Primary Hypertension with Sofren injection.Methods 134 patients were randomly divided into two groups,66 cases as roseroot group and 68 cases as control group;The two groups were given conventional therapy,and the treatment group was given Sofren Injection 10 ml intravenous drip based on routine treatment,1 time a day. The two groups were treated for 2 weeks. then the content of serum hs-CRP and IMT of two groups were analyzed.Results In the roseroot group after treatmen IMT and serum hs-CRP decreased(P<0.05);in the control group after treatmen serum hs-CRP decreased(P<0.05),but IMT showed no significant difference.The content of serum hs-CRP of roseroot group was lower than those of control group after 2 weeks of treatment(P<0.05).The content of IMT of roseroot group and control group showed no significant difference after 2 weeks of treatment,but there is a tendency of decreasing. Conclusion Sofren Injection can cause the Primary Hypertension patients with serum hs-CRP quickly returned to normal level.The mechanism may be related to the blocking inflammatory reaction of atherosclerosis.