CAJ | 학술논문

目的：探讨复方威灵仙（Cpd ．WLX）胶囊对小鼠免疫功能的影响。方法将实验小鼠随机分为Cpd ．WLX胶囊高剂量组（1．8g·kg －1）、Cpd．WLX胶囊中剂量组（0．9g·kg －1）、Cpd．WLX胶囊低剂量组（0．45g·kg －1）、阳性对照组（泼尼松片0．03 g · kg －1）及空白对照组。选用碳廓清实验、溶血素抗体实验、DNFB所致DT H实验模型，观察Cpd ．WLX胶囊对小鼠免疫功效的影响。结果与空白对照组比较，Cpd ．WLX胶囊大、中、小剂量组：碳廓清指数K及校正指数α均显著降低（ P＜0．05，P＜0．01）；上清液在540 nm处的 A值显著降低（P＜0．001）；对DNFB诱导小鼠耳廓肿胀度影响无显著性（P＞0．05）。结论 Cpd ． WLX胶囊在机体非特异性免疫和体液免疫作用方面具有较强的抑制作用。
목적：탐토복방위령선（Cpd ．WLX）효낭대소서면역공능적영향。방법장실험소서수궤분위Cpd ．WLX효낭고제량조（1．8g·kg －1）、Cpd．WLX효낭중제량조（0．9g·kg －1）、Cpd．WLX효낭저제량조（0．45g·kg －1）、양성대조조（발니송편0．03 g · kg －1）급공백대조조。선용탄곽청실험、용혈소항체실험、DNFB소치DT H실험모형，관찰Cpd ．WLX효낭대소서면역공효적영향。결과여공백대조조비교，Cpd ．WLX효낭대、중、소제량조：탄곽청지수K급교정지수α균현저강저（ P＜0．05，P＜0．01）；상청액재540 nm처적 A치현저강저（P＜0．001）；대DNFB유도소서이곽종창도영향무현저성（P＞0．05）。결론 Cpd ． WLX효낭재궤체비특이성면역화체액면역작용방면구유교강적억제작용。
Objective To investigate the effect of Compound Weilingxian Capsules (Cpd .WLX) on immune function in mice .Meth‐ods The mice were randomly divided into 5 groups :high‐dose group (1 .8 g · kg -1 ) ,middle‐dose group (0 .9 g · kg -1 ) ,low‐dose group (0 .45 g · kg -1 ) ,positive control group ( prednisone tablet 0 .03 g · kg -1 ) and blank control group .The effect of Cpd .WLX on immune functions in mice was measured by the carbon clearance experiment ,hemolysin antibody test and dinitroflu‐orobenzene (DNFB) .Results Compared with the blank control group ,high ,middle and low doses of Cpd .WLX significantly de‐creased the level of carbon clearance index (K) and calibration index(α)(P<0 .05 ,P<0 .01);A value tested at 540 nm decreased significantly (P<0 .001);There was no significant effect on swelling degree of DNFB induced mice auricle (P>0 .05) .Conclusion Cpd .WLX had a moderate inhibitor effect on the body′s non‐specific immunity and humoral immunity .