CAJ | 학술논문

磷是生命组成的必需元素，参与了能量代谢、信号转导和蛋白合成等一系列重要的生命过程。肾脏在人体磷稳态的维持中具有重要的功能。慢性肾脏病（CKD）患者普遍伴随着磷代谢紊乱，长期的高磷血症引起继发性甲状旁腺功能亢进症（SHPT）、肾性骨营养不良（ROD）、心血管系统病变（CVD）以及促进肾病的进展，增加了患者的死亡率。近年来，高磷血症作为上述疾病发生的独立危险因素得到了越来越多的关注和研究，进一步提升了慢性肾脏病的治疗效果。
린시생명조성적필수원소，삼여료능량대사、신호전도화단백합성등일계렬중요적생명과정。신장재인체린은태적유지중구유중요적공능。만성신장병（CKD）환자보편반수착린대사문란，장기적고린혈증인기계발성갑상방선공능항진증（SHPT）、신성골영양불량（ROD）、심혈관계통병변（CVD）이급촉진신병적진전，증가료환자적사망솔。근년래，고린혈증작위상술질병발생적독립위험인소득도료월래월다적관주화연구，진일보제승료만성신장병적치료효과。
Phosphorus plays important roles in a variety of biological processes such as energy metabo-lism,cell signaling,nuclenic acid synthesis and membrane function.A major role of the kidney is to maintain phosphorus homeostasis.It is not surprising that when renal function begins to decline in CKD patients,the homeostasis is disrupted and serum concentration of phosphorus begins to increase.Hyper-phosphatemia leads to a series of complications including secondary hyperparathyroidism,renal osteodys-trophy,cardiovascular diseases and progression of CKD,which contributing to the excess mortality of CKD.In recent years,as an independent risk factor of health damage,hyperphosphatemia has attracted more and more concerns.The progression of researches about hyperphosphatemia has promoted the clini-cal therapies of CKD.