中外女性健康研究
中外女性健康研究
중외녀성건강연구
Women's Health Research
2015年
16期
7-9
,共3页
复发性自然流产(RSA)%血栓前状态%血栓标志物%ROC曲线%临界值
複髮性自然流產(RSA)%血栓前狀態%血栓標誌物%ROC麯線%臨界值
복발성자연유산(RSA)%혈전전상태%혈전표지물%ROC곡선%림계치
Recurrent spontaneous abortion (RSA)%Prethrombotic state%Thrombosis marker%ROC curve%Critical value
目的：研究复发性自然流产（Recurrent Spontaneous Abortion，RSA）患者血栓前状态的血栓标志物及其在病例组和对照组之间的最佳临界值。方法：收集郑州人民医院妇产科2012年10月至2014年10月就诊的连续自然流产两次及两次以上的RSA患者血栓标志物资料86例作为病例组，平均年龄（32.72±4.88）岁；同科室正常晚孕且孕周在13~16周之间的孕妇血栓标志物资料176例作为对照组，平均年龄（29.91±4.46）岁。检测抗凝血酶Ⅲ（ATˉⅢ）含量、蛋白C（PC）活性、纤溶酶原（PLG）含量、组织型纤溶酶原激活物（tˉPA）、纤溶酶原活化物抑制因子-1（PAIˉ1）、交联纤维蛋白降解产物（DD）6项血栓指标。采用SPSS 19.0绘制每个指标的ROC曲线，并确定其最佳临界值。采用Logistic回归分析判定指标的灵敏度和特异性。结果：ATˉⅢ、PC、PAIˉ1三个指标的ROC曲线下面积均在70%以上，具有诊断价值；AT的最佳界值为103.175，PC的最佳界值为5.785，PAIˉ1的最佳界值为0.725。三个指标的判别准确率分别为82.8%、96.6%和94.7%。p值均小于0.01，具有统计学意义。结论：ATˉⅢ、PC、PAIˉ1是复发性自然流产的危险因素，对其具有一定的诊断价值。
目的：研究複髮性自然流產（Recurrent Spontaneous Abortion，RSA）患者血栓前狀態的血栓標誌物及其在病例組和對照組之間的最佳臨界值。方法：收集鄭州人民醫院婦產科2012年10月至2014年10月就診的連續自然流產兩次及兩次以上的RSA患者血栓標誌物資料86例作為病例組，平均年齡（32.72±4.88）歲；同科室正常晚孕且孕週在13~16週之間的孕婦血栓標誌物資料176例作為對照組，平均年齡（29.91±4.46）歲。檢測抗凝血酶Ⅲ（ATˉⅢ）含量、蛋白C（PC）活性、纖溶酶原（PLG）含量、組織型纖溶酶原激活物（tˉPA）、纖溶酶原活化物抑製因子-1（PAIˉ1）、交聯纖維蛋白降解產物（DD）6項血栓指標。採用SPSS 19.0繪製每箇指標的ROC麯線，併確定其最佳臨界值。採用Logistic迴歸分析判定指標的靈敏度和特異性。結果：ATˉⅢ、PC、PAIˉ1三箇指標的ROC麯線下麵積均在70%以上，具有診斷價值；AT的最佳界值為103.175，PC的最佳界值為5.785，PAIˉ1的最佳界值為0.725。三箇指標的判彆準確率分彆為82.8%、96.6%和94.7%。p值均小于0.01，具有統計學意義。結論：ATˉⅢ、PC、PAIˉ1是複髮性自然流產的危險因素，對其具有一定的診斷價值。
목적：연구복발성자연유산（Recurrent Spontaneous Abortion，RSA）환자혈전전상태적혈전표지물급기재병례조화대조조지간적최가림계치。방법：수집정주인민의원부산과2012년10월지2014년10월취진적련속자연유산량차급량차이상적RSA환자혈전표지물자료86례작위병례조，평균년령（32.72±4.88）세；동과실정상만잉차잉주재13~16주지간적잉부혈전표지물자료176례작위대조조，평균년령（29.91±4.46）세。검측항응혈매Ⅲ（ATˉⅢ）함량、단백C（PC）활성、섬용매원（PLG）함량、조직형섬용매원격활물（tˉPA）、섬용매원활화물억제인자-1（PAIˉ1）、교련섬유단백강해산물（DD）6항혈전지표。채용SPSS 19.0회제매개지표적ROC곡선，병학정기최가림계치。채용Logistic회귀분석판정지표적령민도화특이성。결과：ATˉⅢ、PC、PAIˉ1삼개지표적ROC곡선하면적균재70%이상，구유진단개치；AT적최가계치위103.175，PC적최가계치위5.785，PAIˉ1적최가계치위0.725。삼개지표적판별준학솔분별위82.8%、96.6%화94.7%。p치균소우0.01，구유통계학의의。결론：ATˉⅢ、PC、PAIˉ1시복발성자연유산적위험인소，대기구유일정적진단개치。
Objective: To explore the thrombus markers of patients with recurrent spontaneous abortion under prethrombotic state and to determine the best threshold between the case group and the control group. Methods: Eighty-six thrombus markers data of patients with RSA, who had consecutive spontaneous abortion twice or more and accepted treatment in the Obstetrics and Gynecology Department of Zhengzhou People's Hospital during October 2012 to October 2014, were collected as the case group, aged 32.72 4.88. Other 176 thrombus markers data of pregnant women, who belonged to normal late pregnancy throng and the gestational weeks was between 13 through 16 weeks, from the same department and aged 29.91 4.46 years old, were regarded as the control group. Six thrombus indexes, Antithrombin Ⅲ (ATˉⅢ), Protein C activity (PC), Plasminogen (PLG) level, tissue type plasminogen activator (tˉPA), PAIˉ1 and DD, were tested. Then ROC curves of each index were drawn by means of SPSS 19.0 software and the best threshold was confirmed. The sensitivities and specificity of the indexes were tested by logistic regression analysis. Results: The area under ROC curves of ATˉIII, PC and PAIˉ1 were more than 70% and it has the diagnostic value. The optimum threshold of AT was 103.175, and that of PC was 5.785, and that of PAIˉI was 0.725. The accuracy was 82.8%, 96.6% and 94.7% respectively. P values of all indexes were lower than 0.01, which meant that it had statistical significance. Conclusion: ATˉⅢ, PC and PAIˉ1 are risk factors of recurrent spontaneous abortion and have certain diagnostic value in it.
