CAJ | 학술논문

目的：探讨内蒙古牧区蒙古族、汉族55岁以上人群血管性危险因素与阿尔茨海默病（ AD）患病的相关性。方法以AD的流行病学调查为基础，同时详细记录受试者的血管性危险因素，采用非条件Logistic回归分析方法对血管性危险因素和AD的关系进行分析。结果在蒙古族55岁以上人群中，脉压指数、糖尿病患病率、冠心病患病率在对照组与AD组之间的差异有统计学意义（ t＝－2.091，P＝0.037；χ2＝7.230，P＝0.007；χ2＝13.859，P＝0.000）；而在汉族55岁以上人群中，对照组与AD组之间脉压指数、冠心病患病率比较差异有统计学意义（ t ＝－2.232， P＝0.026；χ2＝6.951，P＝0.008），对照组糖尿病患病率与AD组之间的差异无统计学意义（ P＞0.05）。多因素分析显示，蒙古族55岁以上人群糖尿病、冠心病在对照组与AD组之间的差异有统计学意义，是AD的危险因素（ OR＝2.423，OR＝2.030，均P＜0.05）；在汉族55岁以上人群中冠心病、脉压指数在对照组与AD组之间的差异同样具有统计学意义，是AD的危险因素（O R＝1.662， OR＝7.078，均P＜0.05）。结论血管性因素可能是中国内蒙古牧区蒙古族、汉族55岁以上人群患AD的危险因素，血管性危险因素可能在AD的发病之中具有协同作用。
목적：탐토내몽고목구몽고족、한족55세이상인군혈관성위험인소여아이자해묵병（ AD）환병적상관성。방법이AD적류행병학조사위기출，동시상세기록수시자적혈관성위험인소，채용비조건Logistic회귀분석방법대혈관성위험인소화AD적관계진행분석。결과재몽고족55세이상인군중，맥압지수、당뇨병환병솔、관심병환병솔재대조조여AD조지간적차이유통계학의의（ t＝－2.091，P＝0.037；χ2＝7.230，P＝0.007；χ2＝13.859，P＝0.000）；이재한족55세이상인군중，대조조여AD조지간맥압지수、관심병환병솔비교차이유통계학의의（ t ＝－2.232， P＝0.026；χ2＝6.951，P＝0.008），대조조당뇨병환병솔여AD조지간적차이무통계학의의（ P＞0.05）。다인소분석현시，몽고족55세이상인군당뇨병、관심병재대조조여AD조지간적차이유통계학의의，시AD적위험인소（ OR＝2.423，OR＝2.030，균P＜0.05）；재한족55세이상인군중관심병、맥압지수재대조조여AD조지간적차이동양구유통계학의의，시AD적위험인소（O R＝1.662， OR＝7.078，균P＜0.05）。결론혈관성인소가능시중국내몽고목구몽고족、한족55세이상인군환AD적위험인소，혈관성위험인소가능재AD적발병지중구유협동작용。
Objective To investigate the relationship between vascular risk factors and Alzheimer′s disease(AD) in Mongolian and Han population over 55 years old living in Inner Mongolia pastoral areas . Methods Based on the epidemiological investigation of AD ,the subjects′vascular risk factors were recoded in detail and non-conditional logistic regression analysis was adopted to analyze the relation between vascular risk factors and AD.Rse ults Among the people of Mongolian nationality aged over 55,there were statistical differences in pulse pressure index , diabetes rate and coronary heart disease ( CHD ) rate between control group and AD group ( t=-2.091 , P=0.037;χ2 =7.230 , P =0.007;χ2 =13.859 , P=0.000 );In Han nationality′s people aged over 55, there was statistical difference in pulse pressure index and CHD rate between control group and AD group ( t =-2.232 , P =0.026;χ2 =6.951 , P =0.008 ) .There was no statistical difference in diabetes between control group and AD group ( P >0.05 ) .Multivariate analysis showed that the differences of diabetes and CHD between control group and AD group had statistically significance in Mongolian populations aged over 55,diabetes and CHD were risk factors of AD (OR=2.423, OR=2.030 , all P<0.05 );The differences of CHD , pulse pressure index between control group and AD group also had statistically significant in Han populations aged over 55,CHD,pulse pressure index were risk factors of AD(OR=1.662,OR=7.078,all P<0.05).Conclusion Vascular factors may be the risk factors of the Mongolian nationality and Han Nationality population aged over 55 living in Inner Mongolia pastoral areas,which may have a synergistic effect on the pathogenesis of AD .