CAJ | 학술논문

动脉粥样硬化作为一种复杂的炎症性疾病，已严重威胁人类健康。肿瘤坏死因子α是一种多效性的细胞因子，可通过多种信号通路介导炎症反应。大量研究表明，肿瘤坏死因子α能够诱导血管内皮细胞、血管平滑肌细胞的损伤，诱导单核细胞的迁移并与内皮细胞黏附以及泡沫细胞的形成，同时还能影响斑块的稳定性，深度参与动脉粥样硬化的形成和发展。文章就近年来肿瘤坏死因子α介导动脉粥样硬化发生机制的研究予以综述。
동맥죽양경화작위일충복잡적염증성질병，이엄중위협인류건강。종류배사인자α시일충다효성적세포인자，가통과다충신호통로개도염증반응。대량연구표명，종류배사인자α능구유도혈관내피세포、혈관평활기세포적손상，유도단핵세포적천이병여내피세포점부이급포말세포적형성，동시환능영향반괴적은정성，심도삼여동맥죽양경화적형성화발전。문장취근년래종류배사인자α개도동맥죽양경화발생궤제적연구여이종술。
Atherosclerosis,which is the main consequence of a complicated inflammatory process,has threatened human health seriously.Tumor necrosis factor alpha is a multifunctional cytokine which is regarded to mediate the inflammatory response by acti-vating various signaling pathways.A large number of studies showed that tumor necrosis factor alpha could not only induce the in-jure of vascular endothelial cells and vascular smooth muscle cells,but also induced the migration of monocytes and endothelial cell adhesion and foam cell formation.At the same time,the stability of the plaque may also be affected,tumor necrosis factor alpha crucially involved in the pathogenesis and progression of atherosclerosis.This article made a review on the studies researched on pathogenesis of atherosclerosis due to tumor necrosis factor alpha.