中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
Chinese Journal of General Surgery
2015年
8期
643-646
,共4页
李锟%李玫%刘玉兰%马淑云%郁卫东
李錕%李玫%劉玉蘭%馬淑雲%鬱衛東
리곤%리매%류옥란%마숙운%욱위동
结直肠肿瘤%病理学,临床%预后%免疫组织化学
結直腸腫瘤%病理學,臨床%預後%免疫組織化學
결직장종류%병이학,림상%예후%면역조직화학
Colorectal neoplasms%Pathology,clinical%Prognosis%Immunohistochemistry
目的 分析Abl相互作用蛋白1(Abl interactor 1,ABI1)表达与结直肠腺癌临床病理特征和预后的相关性.方法 应用免疫组织化学技术,检测ABI1蛋白在218例结直肠腺癌组织中的表达,利用x2检验及Spearman相关检验,分析ABI1表达与结直肠腺癌临床病理特点的相关性[x2和(或)Fisher检验及Spearman相关检验],应用Kaplan-Meier方法计算其中109例结直肠腺癌患者术后5年生存率及生存时间.结果 相对于癌旁组织,ABI1在结直肠腺癌中的表达明显上调(P=0.000);ABI1表达与结直肠腺癌浸润深度(P =0.040)和组织分化程度(P =0.043)显著相关,而与肿瘤部位、临床分期、淋巴结和远处转移等无相关性;高表达和低表达ABI1的患者术后5年累积生存率分别为45.6％和76.9％,中位生存时间为71.6 (95％ CI:57.4 ～ 85.7)个月和99.0 (95％ CI:85.6～112.4)个月,Kaplan-Meier分析显示,差异有统计学意义(x2=11.090,P=0.001).多因素分析显示,ABI1不是一个独立的结直肠癌预后评估因素(P=0.119).结论 结直肠腺癌组织中表达的显著上调提示ABI1具有潜在的促癌作用;ABI1表达上调与结直肠腺癌的浸润程度、组织分化程度和患者生存时间相关.
目的 分析Abl相互作用蛋白1(Abl interactor 1,ABI1)錶達與結直腸腺癌臨床病理特徵和預後的相關性.方法 應用免疫組織化學技術,檢測ABI1蛋白在218例結直腸腺癌組織中的錶達,利用x2檢驗及Spearman相關檢驗,分析ABI1錶達與結直腸腺癌臨床病理特點的相關性[x2和(或)Fisher檢驗及Spearman相關檢驗],應用Kaplan-Meier方法計算其中109例結直腸腺癌患者術後5年生存率及生存時間.結果 相對于癌徬組織,ABI1在結直腸腺癌中的錶達明顯上調(P=0.000);ABI1錶達與結直腸腺癌浸潤深度(P =0.040)和組織分化程度(P =0.043)顯著相關,而與腫瘤部位、臨床分期、淋巴結和遠處轉移等無相關性;高錶達和低錶達ABI1的患者術後5年纍積生存率分彆為45.6％和76.9％,中位生存時間為71.6 (95％ CI:57.4 ～ 85.7)箇月和99.0 (95％ CI:85.6～112.4)箇月,Kaplan-Meier分析顯示,差異有統計學意義(x2=11.090,P=0.001).多因素分析顯示,ABI1不是一箇獨立的結直腸癌預後評估因素(P=0.119).結論 結直腸腺癌組織中錶達的顯著上調提示ABI1具有潛在的促癌作用;ABI1錶達上調與結直腸腺癌的浸潤程度、組織分化程度和患者生存時間相關.
목적 분석Abl상호작용단백1(Abl interactor 1,ABI1)표체여결직장선암림상병리특정화예후적상관성.방법 응용면역조직화학기술,검측ABI1단백재218례결직장선암조직중적표체,이용x2검험급Spearman상관검험,분석ABI1표체여결직장선암림상병리특점적상관성[x2화(혹)Fisher검험급Spearman상관검험],응용Kaplan-Meier방법계산기중109례결직장선암환자술후5년생존솔급생존시간.결과 상대우암방조직,ABI1재결직장선암중적표체명현상조(P=0.000);ABI1표체여결직장선암침윤심도(P =0.040)화조직분화정도(P =0.043)현저상관,이여종류부위、림상분기、림파결화원처전이등무상관성;고표체화저표체ABI1적환자술후5년루적생존솔분별위45.6％화76.9％,중위생존시간위71.6 (95％ CI:57.4 ～ 85.7)개월화99.0 (95％ CI:85.6～112.4)개월,Kaplan-Meier분석현시,차이유통계학의의(x2=11.090,P=0.001).다인소분석현시,ABI1불시일개독립적결직장암예후평고인소(P=0.119).결론 결직장선암조직중표체적현저상조제시ABI1구유잠재적촉암작용;ABI1표체상조여결직장선암적침윤정도、조직분화정도화환자생존시간상관.
Objective To analyze the correlation between the expression of Abl interactor 1 (ABI1) and the clinicopathologic characteristics in colorectal adenocarcinoma tissues.Methods Immunohistochemistry was used to determine ABI1 expression in human colorectal adenocarcinoma tissues and matched adjacent tissues.A statistical analysis was used to determine the potential correlation between ABI1 expression and clinicopathological characteristics and prognosis.Results ABI1 is up-regulated in colorectal adenocarcinoma tissues compared with matched adjacent tissues (P =0.000),ABI1 expression is significantly correlated with infiltration (P =0.043) and differentiation (P =0.040),but not with sex,age,tumor location,clinical stage,lymph node metastasis and distant metastasis (P ＞0.05);It was also shown that ABI1 expression had a significant influence on prognosis (x2 =11.090,P =0.001).Multivariate analyses showed that high ABI1 expression is not an independent poor prognostic factor for overall survival (P =0.119).Conclusion ABI1 overexpression might act as pro-oncogene for patients with colorectal adenocarcinoma.
