CAJ | 학술논문

目的探讨石家庄地区女性宫颈人乳头瘤病毒(HPV)感染的基因型分布情况,为预防HPV感染和宫颈疾病防治提供理论依据.方法使用核酸分子快速导流杂交基因芯片技术,对5092例女性宫颈脱落细胞进行HPV亚型检测.结果 1902例患者感染HPV,总感染率为37.4％.高危型HPV感染率为32.54％,居前5位的HPV基因亚型依次为HPV16、58、52、53和18.低危型HPV感染率为11.67％,主要基因亚型为HPV6和11.单一感染1229例(24.1％),双重感染448例(8.8％),多重感染225例(4.4％).HPV感染以≤40岁的年轻女性为主(76.2％),≤25岁患者HPV感染率最高(47.9％).结论 HPV16、HPV58、HPV52、HPV6和HPV53感染在石家庄地区最为常见,总体符合亚洲人群分布规律,同时又具有独特的地域分布特点.
목적 탐토석가장지구녀성궁경인유두류병독(HPV)감염적기인형분포정황,위예방HPV감염화궁경질병방치제공이론의거.방법 사용핵산분자쾌속도류잡교기인심편기술,대5092례녀성궁경탈락세포진행HPV아형검측.결과 1902례환자감염HPV,총감염솔위37.4％.고위형HPV감염솔위32.54％,거전5위적HPV기인아형의차위HPV16、58、52、53화18.저위형HPV감염솔위11.67％,주요기인아형위HPV6화11.단일감염1229례(24.1％),쌍중감염448례(8.8％),다중감염225례(4.4％).HPV감염이≤40세적년경녀성위주(76.2％),≤25세환자HPV감염솔최고(47.9％).결론 HPV16、HPV58、HPV52、HPV6화HPV53감염재석가장지구최위상견,총체부합아주인군분포규률,동시우구유독특적지역분포특점.
Objective To provide the theoretical basis for preventing human papillomavirus (HPV)infection and treating uterine cervical disease by investigating genotypes of HPV among women in Shijiazhuang city.Methods HPV genotype of 5092 cases of cervical cell was detected by nucleic acid molecule flow-through hybridization and gene chip technique.Results 1902 cases were infected by HPV,with the positive rate of 37.4％.The infection rate of high-risk subtypes of HPV was 32.54％,with the top five subtypes of HPV16,58,52,53 and 18.The infection rate of low-risk subtypes of HPV was 11.67％,with the top two subtypes of HPV6 and 11.There were 1229 cases(24.1％)with single HPV type infection,448 cases(8.8％) with double HPV subtypes infection,225 cases (4.4％) with multiple HPV subtypes infection.The majority cases with HPV infection were young women of age ≤40.Patients younger than 25 years old had the highest HPV infection rate of 47.9％.Conclusions HPV16,58,52,6 and 53 are major subtypes in Shijiazhuang city,which is in accord with the overall distribution among Asian population,but also has a unique regional distribution characteristic.