CAJ | 학술논문

目的：探讨血液净化在急性脑出血治疗中的作用及其疗效。方法比较血液净化组（A组）与常规治疗组（B组）患者3，7，14天的全身炎症反应综合征（SIRS）情况以及超敏C-反应蛋白（hs-CRP），白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的差异和病死率。采用NIHSS（National Institutes of Health Stroke）和ADL量表评估两组患者在治疗前后的神经功能及生活质量的变化。结果 A组患者经血液净化治疗3，7，14天后SIRS好转率高于B组，差异有统计学意义（P＜0.05），hs-CRP，IL-6和TNF-α水平及病死率均低于B组，差异有统计学意义（P＜0.05）。A组患者在治疗前后的神经功能改善情况较B组更为明显，差异有统计学意义（P＜0.05）。结论血液净化可有效清除脑出血患者的炎症因子，改善患者预后恢复，降低死亡率，对急性脑出血的治疗意义重大。
목적：탐토혈액정화재급성뇌출혈치료중적작용급기료효。방법비교혈액정화조（A조）여상규치료조（B조）환자3，7，14천적전신염증반응종합정（SIRS）정황이급초민C-반응단백（hs-CRP），백개소-6（IL-6）화종류배사인자-α（TNF-α）적차이화병사솔。채용NIHSS（National Institutes of Health Stroke）화ADL량표평고량조환자재치료전후적신경공능급생활질량적변화。결과 A조환자경혈액정화치료3，7，14천후SIRS호전솔고우B조，차이유통계학의의（P＜0.05），hs-CRP，IL-6화TNF-α수평급병사솔균저우B조，차이유통계학의의（P＜0.05）。A조환자재치료전후적신경공능개선정황교B조경위명현，차이유통계학의의（P＜0.05）。결론혈액정화가유효청제뇌출혈환자적염증인자，개선환자예후회복，강저사망솔，대급성뇌출혈적치료의의중대。
Objective To investigate the role of blood purification in the treatment of acute intracerebral hemorrhage and its curative effect.Methods The mortality,condition of SIRS in 3 d,7 d and 14 d,and differences among hs-CRP,IL-6 and TNF-αlevers of the blood puriifcation group(group A)and the common treatment group(group B)were compared respectively.Neural function and changes in life quality before and after therapy were assessed by NIHSS and ADL scale.Results Improvement rate of SIRS in group A was larger than that in group B in 3 d, 7 d and 14 d after blood puriifcation treatment(P<0.05).Mortality and levers of hs-CRP, IL-6 and TNF-αin group A were smaller than those in group B(P<0.05).Improvement of neurological function before and after therapy in group A was more signiifcant than that in group B(P<0.05).Conclusion Blood puriifcation not only enables to effectively clear inflammatory factors in patients with intracerebral hemorrhage,but also by aiding conventional therapy,improves the prognosis of recovery in patients,as well as reduces the mortality,which is of vital importance in the treatment of acute intracerebral hemorrhage.