CAJ | 학술논문

维生素K1（ vitamin K1， VK1）和维生素K2（ vitamin K2， VK2）是自然存在的维生素K （ vita-min K， VK）的两种主要结构，除参与肝脏凝血因子的合成，还在骨组织代谢中发挥着重要作用。细胞及动物实验均发现VK能过促进成骨过程，抑制骨吸收，并在临床应用于骨质疏松症的治疗。其作用机制除VK促进骨钙素等成骨相关蛋白的γ-羧化外，还可激活类固醇异生物受体，诱导成骨相关基因的表达。另外， mi-croRNA-133 a同时参与了VK的代谢过程及骨代谢过程，可能是VK调节骨代谢的一个重要途径。
유생소K1（ vitamin K1， VK1）화유생소K2（ vitamin K2， VK2）시자연존재적유생소K （ vita-min K， VK）적량충주요결구，제삼여간장응혈인자적합성，환재골조직대사중발휘착중요작용。세포급동물실험균발현VK능과촉진성골과정，억제골흡수，병재림상응용우골질소송증적치료。기작용궤제제VK촉진골개소등성골상관단백적γ-최화외，환가격활류고순이생물수체，유도성골상관기인적표체。령외， mi-croRNA-133 a동시삼여료VK적대사과정급골대사과정，가능시VK조절골대사적일개중요도경。
Vitamin K1 and vitamin K2 are two structures of vitamin K (VK) in nature, besides the action in the coagulation factors synthesis in the liver , they also play an important role in bone metabolism .In vitro and animal experi-ments indicted VK can promote bone formation and inhibit bone resorption .VK has achieved great success for treatment of osteoporosis and prevention for osteoporotic fracture clinically .The mechanism of these actions include the participation of gamma carboxylation of the VK-dependent proteins such as osteocalcin and the induction of gene expression through the activation of steroid xenobiotic receptor .Otherwise , microRNA-133 a may be an important pathway of these actions .