CAJ | 학술논문

[目的]研究热休克蛋白27（HSP27）和p53在胃癌组织中的表达及与胃癌生物学行为关系。[方法]采用免疫组化SABC法检测48例胃癌（胃癌组）、20例正常胃黏膜（对照组）组织中HSP27和p53的蛋白表达。[结果] H S P 27、p53蛋白表达阳性率，胃癌组分别为64.6％、68.9％，对照组分别为7.1％、0％，2组比较差异有统计学意义（P＜0.01）；HSP27在胃癌中表达与肿瘤浸润深度、淋巴结转移及临床分期有关（P＜0.05），p53蛋白在胃癌中表达与肿瘤大小、部位、浸润深度、淋巴结转移和肿瘤增殖能力有关（ P＜0.05），H S P27与p53的表达无相关性。[结论]H S P27和p53表达与胃癌生物学行为有关，在胃癌的发生、发展过程中发挥着重要的作用。
[목적]연구열휴극단백27（HSP27）화p53재위암조직중적표체급여위암생물학행위관계。[방법]채용면역조화SABC법검측48례위암（위암조）、20례정상위점막（대조조）조직중HSP27화p53적단백표체。[결과] H S P 27、p53단백표체양성솔，위암조분별위64.6％、68.9％，대조조분별위7.1％、0％，2조비교차이유통계학의의（P＜0.01）；HSP27재위암중표체여종류침윤심도、림파결전이급림상분기유관（P＜0.05），p53단백재위암중표체여종류대소、부위、침윤심도、림파결전이화종류증식능력유관（ P＜0.05），H S P27여p53적표체무상관성。[결론]H S P27화p53표체여위암생물학행위유관，재위암적발생、발전과정중발휘착중요적작용。
Objective]To investigate the relationship between the expression of HSP27/p53 and the bi‐ological behavior in gastric carcinoma. [Methods]Immunohistochemical technique SABC method was used to detect the expression of HSP27 and p53 in 48 cases with gastric carcinoma. [Results]The positive rates of HSP27 and p53 were 64.6% and 68.9% in gastric carcinoma respectively. The expression of HSP27 was related to the depth of tumor invasion ,lymph node metastasis and TNM stage(P<0.05). The expression of p53 was significantly correlated with tumor size ,location ,the depth of tumor invasion ,lymph node me‐tastasis and tumors'proliferative capacity(P<0.05).[Conclusion]The expression of HSP27 and p53 corre‐lated with the biological behavior of gastric carcinoma. They play an important role in the genesis and pro‐gress of gastric carcinoma.