临床消化病杂志
臨床消化病雜誌
림상소화병잡지
Chinese Journal of Clinical Gastroenterology
2015年
4期
209-211,212
,共4页
上腹痛综合征%埃索美拉唑%氟哌噻吨美利曲辛片%心理状态%睡眠质量
上腹痛綜閤徵%埃索美拉唑%氟哌噻噸美利麯辛片%心理狀態%睡眠質量
상복통종합정%애색미랍서%불고새둔미리곡신편%심리상태%수면질량
epigastric pain syndrome%esomeprazole%flupentixol melitracen piece%mental state%sleep quality
[目的]观察氟哌噻吨美利曲辛片联合质子泵抑制剂对上腹痛综合征患者睡眠和心理状态及临床症状、疗效的影响。[方法]随机将118例上腹痛综合征患者分为对照组与观察组，每组59例。对照组采用埃索美拉唑20 mg治疗，1次／d；观察组在对照组治疗基础上加用氟哌噻吨美利曲辛片治疗，早、中各1片；2组均治疗8周。比较2组治疗前、治疗第4周末、第8周末临床症状、心理状态、睡眠质量，治疗第8周末临床疗效及不良反应。[结果]2组患者治疗后第4周末、第8周末临床症状评分和焦虑、抑郁及睡眠质量均较治疗前明显改善，具有统计学意义（P＜0．05）；而观察组第4周末、第8周末各项指标改善较对照组显著（P＜0．05）。观察组临床治疗有效率94．92％（56／59）明显高于对照组79．66％（47／59），具有统计学意义（ P＜0．05）。2组治疗期间均未发生严重性不良反应。[结论]采用氟哌噻吨美利曲辛片联合埃索美拉唑治疗上腹痛综合征可有效改善患者临床焦虑及抑郁情绪，提高临床疗效，具有较高安全性。
[目的]觀察氟哌噻噸美利麯辛片聯閤質子泵抑製劑對上腹痛綜閤徵患者睡眠和心理狀態及臨床癥狀、療效的影響。[方法]隨機將118例上腹痛綜閤徵患者分為對照組與觀察組，每組59例。對照組採用埃索美拉唑20 mg治療，1次／d；觀察組在對照組治療基礎上加用氟哌噻噸美利麯辛片治療，早、中各1片；2組均治療8週。比較2組治療前、治療第4週末、第8週末臨床癥狀、心理狀態、睡眠質量，治療第8週末臨床療效及不良反應。[結果]2組患者治療後第4週末、第8週末臨床癥狀評分和焦慮、抑鬱及睡眠質量均較治療前明顯改善，具有統計學意義（P＜0．05）；而觀察組第4週末、第8週末各項指標改善較對照組顯著（P＜0．05）。觀察組臨床治療有效率94．92％（56／59）明顯高于對照組79．66％（47／59），具有統計學意義（ P＜0．05）。2組治療期間均未髮生嚴重性不良反應。[結論]採用氟哌噻噸美利麯辛片聯閤埃索美拉唑治療上腹痛綜閤徵可有效改善患者臨床焦慮及抑鬱情緒，提高臨床療效，具有較高安全性。
[목적]관찰불고새둔미리곡신편연합질자빙억제제대상복통종합정환자수면화심리상태급림상증상、료효적영향。[방법]수궤장118례상복통종합정환자분위대조조여관찰조，매조59례。대조조채용애색미랍서20 mg치료，1차／d；관찰조재대조조치료기출상가용불고새둔미리곡신편치료，조、중각1편；2조균치료8주。비교2조치료전、치료제4주말、제8주말림상증상、심리상태、수면질량，치료제8주말림상료효급불량반응。[결과]2조환자치료후제4주말、제8주말림상증상평분화초필、억욱급수면질량균교치료전명현개선，구유통계학의의（P＜0．05）；이관찰조제4주말、제8주말각항지표개선교대조조현저（P＜0．05）。관찰조림상치료유효솔94．92％（56／59）명현고우대조조79．66％（47／59），구유통계학의의（ P＜0．05）。2조치료기간균미발생엄중성불량반응。[결론]채용불고새둔미리곡신편연합애색미랍서치료상복통종합정가유효개선환자림상초필급억욱정서，제고림상료효，구유교고안전성。
Objective]Observing the effect of flupentixol and melitracen tablets combined with proton pump inhibitor on the sleeping and psychological conditions ,clinical symptoms in patients with epigastric pain .[Methods]Total 118 patients with epigasric pain syndromes were randomly divided into control group and observation group ,59 cases in each group .The control group was treated with esomeprazole 20 mg , once daily .Patients in the observation group was additionally treated with flupentixol and melitracen tab‐lets at the dose of twice daily .Both groups were treated for eight weeks .The clinical symptoms ,psychologi‐cal conditions and sleeping qualities of the two groups before the medical treatment and on the fourth and eighth weekends of the medical treatment were compared .[Results]The clinical symptoms score of and the qualities of anxiety ,depression and sleeping at end of the fourth and eighth week in both groups were sig‐nificantly improved in comparing with which before the treatment (P< 0 .05) .The improvement of the va‐rious indices in the observation group at the end of the fourth and eighth week were higher than those in the control group(P< 0 .05) .The effective rate of the clinical treatment in the observation group was 94 .92% (56/59) ,which was significantly higher than that in the control group 79 .66% (47/59 ,P<0 .05) . There were no severe adverse reactions during the medical treatment periods in the two groups .[Conclusion]Flu‐pentixol and melitracen tablets combined with the esomeprazole can effectively improve the anxiety and depression complaints and enhance the therapeutic effectiveness in patients with epigastric pain syndrome .
