CAJ | 학술논문

目的：探讨乳腺浸润性导管癌超声特征与分子生物学指标ER、PR、C-erbB-2及Ki-67之间的相关性。方法：收集本院2012年1月-2014年6月收治的107例女性乳腺浸润性导管癌患者的临床资料，对其超声资料及分子病理学指标进行分析。结果：有毛刺征患者的ER、PR阳性表达率均高于无毛刺征患者，有微钙化征患者ER、C-erbB-2及Ki-67的阳性表达率均高于无微钙化患者，有可疑淋巴结患者的C-erbB-2阳性表达率高于无可疑淋巴结患者，血流信号丰富患者的C-erbB-2阳性表达率明显高于血流信号不丰富患者，以上比较差异均有统计学意义（P<0.05）。结论：乳腺浸润性导管癌超声表现与分子生物学指标之间存在一定的相关性，通过超声特征可预测此类乳腺癌细胞ER、PR、C-erbB-2及Ki-67的表达情况，为临床评估患者的生物学行为和预后、指导综合治疗方案提供参考。
목적：탐토유선침윤성도관암초성특정여분자생물학지표ER、PR、C-erbB-2급Ki-67지간적상관성。방법：수집본원2012년1월-2014년6월수치적107례녀성유선침윤성도관암환자적림상자료，대기초성자료급분자병이학지표진행분석。결과：유모자정환자적ER、PR양성표체솔균고우무모자정환자，유미개화정환자ER、C-erbB-2급Ki-67적양성표체솔균고우무미개화환자，유가의림파결환자적C-erbB-2양성표체솔고우무가의림파결환자，혈류신호봉부환자적C-erbB-2양성표체솔명현고우혈류신호불봉부환자，이상비교차이균유통계학의의（P<0.05）。결론：유선침윤성도관암초성표현여분자생물학지표지간존재일정적상관성，통과초성특정가예측차류유선암세포ER、PR、C-erbB-2급Ki-67적표체정황，위림상평고환자적생물학행위화예후、지도종합치료방안제공삼고。
Objective:To investigate the correlations between ultrasonographic features and molecular biological indexes such as ER(estrogen receptor),PR(progesterone receptor),C-erbB-2 (human epidermal growth factor receptor 2)and Ki-67 in invasive duct carcinoma of breast(IDC).Method:The data of 107 IDC patients who were in our hospital from January 2012 to June 2014 were collected.Their ultrasonographic data and immunohistochemical pathologic results were analyzed.Result:The positive expression rates of ER,PR in patients with spiculation were higher than those in patients without spiculation,the positive expression rates of ER,C-erbB-2 and Ki-67 in patients with microcalcification were higher than those in patients without microcalcification,the positive expression rate of C-erbB-2 in patients with suspicious lymph node was higher than that in patients without suspicious lymph node,the positive expression rate of C-erbB-2 in patients with rich blood flow signals was higher than that in patients with poor blood flow signals,the differences above were all statistically significant(P<0.05).Conclusion:There is a certain correlation between ultrasonographic features and molecular biology markers in invasive duct carcinoma of breast. The expression results of ER,PR,C-erbB-2 and Ki-67 of IDC can be predicted according to the ultrasonographic features,which can provide a basis for the biologic behavior assessment,prognosis and clinical treatment.