CAJ | 학술논문

干细胞具有自我更新能力和多向分化潜能,能通过非对称分裂的方式产生功能和类型更为局限的前体细胞及多种细胞系,进而再生新的细胞,参与损伤组织的修复和重建,是细胞移植研究和再生医学研究的主要对象.眼是一种由多种组织细胞和神经细胞组成的感觉器官,干细胞移植治疗眼科变性性疾病具有易操作、可视性好、所需种子细胞量少和排斥反应轻的优点,在干细胞基础研究和临床研究中受到广泛关注.国内外研究团队正在进行干细胞移植治疗眼部不可逆疾病的Ⅰ、Ⅱ期临床试验,我国经WHO注册的Ⅰ期临床试验也正处于病例招募阶段,以评估干细胞移植治疗眼部疾病的疗效和安全性.目前,关于干细胞移植治疗眼部疾病的研究仍存在很多尚需解决的问题.本文中评述眼科干细胞移植研究的进展以及进一步的研究方向.
간세포구유자아경신능력화다향분화잠능,능통과비대칭분렬적방식산생공능화류형경위국한적전체세포급다충세포계,진이재생신적세포,삼여손상조직적수복화중건,시세포이식연구화재생의학연구적주요대상.안시일충유다충조직세포화신경세포조성적감각기관,간세포이식치료안과변성성질병구유역조작、가시성호、소수충자세포량소화배척반응경적우점,재간세포기출연구화림상연구중수도엄범관주.국내외연구단대정재진행간세포이식치료안부불가역질병적Ⅰ、Ⅱ기림상시험,아국경WHO주책적Ⅰ기림상시험야정처우병례초모계단,이평고간세포이식치료안부질병적료효화안전성.목전,관우간세포이식치료안부질병적연구잉존재흔다상수해결적문제.본문중평술안과간세포이식연구적진전이급진일보적연구방향.
Stem cells are a group of undifferentiated cells with indefinite self-renewal and pluripotent differentiation ability.They are able to differentiate into precursor/progenitor cells and a variety of cell types and further regenerate new cells to be involved in the repair and rebuilding of injured tissue.Therefore,stem cells are becoming the major research objects in the study on tissue engineering therapy and regenerative medicine.As a sense organ composed of several kinds of neurons and other cells,eyes possesse the dominant superiority in stem cell transplantation therapy because of its good operation controllability and visuality,less demand for seed cells and low rejection after transplantation.These advantages have aroused growing interesting of the fundamental research and clinical trail in stem cell transplantation for irreversible eye diseases.Some exciting advances in the field of stem cell fundamental research,several phase Ⅰ/Ⅱ clinical trials are in progress.The patients with degenerative eye diseases for phase Ⅰ clinical trials are in recruiting in China to evaluate future curative effect and security of stem cell-based therapies.Currently,several issues in stem cell-based eye disease therapies are still pending.We discuss the updated development of stem cell-based transplantation in ophthalmology and future researching direction in order to help ophthalmological researchers to understand the concepts and research strategies.