河南医学研究
河南醫學研究
하남의학연구
Henan Medical Research
2015年
9期
13-16,17
,共5页
余淼%薛焕洲%王亚东%张晓
餘淼%薛煥洲%王亞東%張曉
여묘%설환주%왕아동%장효
布加综合征%原发性肝癌%甲胎蛋白%受试者工作特征曲线
佈加綜閤徵%原髮性肝癌%甲胎蛋白%受試者工作特徵麯線
포가종합정%원발성간암%갑태단백%수시자공작특정곡선
Budd -Chiari syndrome%hepatocellular carcinoma%α-fetoprotein%Receiver operating characteristic curve
目的:比较健康人群组、布加综合征(BCS)组、原发性肝癌(HCC)组、布加综合征合并原发性肝癌(BCS 合并HCC)组患者血清 AFP 水平有无差异,探讨血清 AFP 浓度在布加综合征合并原发性肝癌患者中的临床意义。方法采用回顾性研究方法,收集1998年3月至2015年3月河南省人民医院198例患者的血清甲胎蛋白(AFP),分为 BCS 组77例、HCC 组90例和 BCS 合并 HCC 组31例。对照组为河南省血液中心的84例健康献血者。排除性别等一般条件的差异。使用 SPSS 17.0统计软件包进行数据统计分析,GraphPadPrism 5软件绘制散点图。绘制受试者工作特征曲线(ROC),并计算曲线下面积(AUC)。结果①BCS 组与对照组血清 AFP 浓度差异无统计学意义(P >0.05)。②绘制BCS 合并 HCC 组对健康人群组的 ROC 曲线,AUC =0.852。当血清 AFP 的切割点值为300 ng/ml 时,敏感度为0.80,特异度为0.87,约登指数为0.67,准确度为0.86,诊断效能最高。结论血清 AFP 是 BCS 合并 HCC 患者的一个重要血清学检测指标。当临界值设定为300 ng/ml 时,对 BCS 合并 HCC 的效能最高。
目的:比較健康人群組、佈加綜閤徵(BCS)組、原髮性肝癌(HCC)組、佈加綜閤徵閤併原髮性肝癌(BCS 閤併HCC)組患者血清 AFP 水平有無差異,探討血清 AFP 濃度在佈加綜閤徵閤併原髮性肝癌患者中的臨床意義。方法採用迴顧性研究方法,收集1998年3月至2015年3月河南省人民醫院198例患者的血清甲胎蛋白(AFP),分為 BCS 組77例、HCC 組90例和 BCS 閤併 HCC 組31例。對照組為河南省血液中心的84例健康獻血者。排除性彆等一般條件的差異。使用 SPSS 17.0統計軟件包進行數據統計分析,GraphPadPrism 5軟件繪製散點圖。繪製受試者工作特徵麯線(ROC),併計算麯線下麵積(AUC)。結果①BCS 組與對照組血清 AFP 濃度差異無統計學意義(P >0.05)。②繪製BCS 閤併 HCC 組對健康人群組的 ROC 麯線,AUC =0.852。噹血清 AFP 的切割點值為300 ng/ml 時,敏感度為0.80,特異度為0.87,約登指數為0.67,準確度為0.86,診斷效能最高。結論血清 AFP 是 BCS 閤併 HCC 患者的一箇重要血清學檢測指標。噹臨界值設定為300 ng/ml 時,對 BCS 閤併 HCC 的效能最高。
목적:비교건강인군조、포가종합정(BCS)조、원발성간암(HCC)조、포가종합정합병원발성간암(BCS 합병HCC)조환자혈청 AFP 수평유무차이,탐토혈청 AFP 농도재포가종합정합병원발성간암환자중적림상의의。방법채용회고성연구방법,수집1998년3월지2015년3월하남성인민의원198례환자적혈청갑태단백(AFP),분위 BCS 조77례、HCC 조90례화 BCS 합병 HCC 조31례。대조조위하남성혈액중심적84례건강헌혈자。배제성별등일반조건적차이。사용 SPSS 17.0통계연건포진행수거통계분석,GraphPadPrism 5연건회제산점도。회제수시자공작특정곡선(ROC),병계산곡선하면적(AUC)。결과①BCS 조여대조조혈청 AFP 농도차이무통계학의의(P >0.05)。②회제BCS 합병 HCC 조대건강인군조적 ROC 곡선,AUC =0.852。당혈청 AFP 적절할점치위300 ng/ml 시,민감도위0.80,특이도위0.87,약등지수위0.67,준학도위0.86,진단효능최고。결론혈청 AFP 시 BCS 합병 HCC 환자적일개중요혈청학검측지표。당림계치설정위300 ng/ml 시,대 BCS 합병 HCC 적효능최고。
Objective To compare the levels of serun AFP among patients with Budd -Chiari syndrome,hepatocellular car-cinoma,Budd -Chiari syndrome complicated by hepatocellular carcinoma and healthy volunteers,and evaluate the effect of AFP levels in the diagnosis of Budd -Chiari syndrome complicated by hepatocellular carcinoma.Methods From March of 1 998 to March of 201 5,1 98 patients were retrospectively analyzed and divided into three groups:HCC group (n =77),BCS group (n =90)and HCC complicated by HCC group (n =31 ).84 healthy volunteers were selected as control group.The AFP values of dif-ferent groups were analyzed by Software SPSS 1 7.0,and the scatterplot was made by Software GraphPad Prism 5.The receiver -operating characteristic curve (receiver operating characteristic curve,ROC)was drew,and the area under the curve (area under curve,AUC)was calculated.Results ①The difference of AFP values between BCS group and control group was not statistically significant(P >0.05).②AUC of receiver operator charac-teristic curve (ROC)was 0.852.When the cutoff value of AFP was set at 300 ng/ml as the best critical value for the diagnosis of BCS complicated by HCC,the sensitivity,specificity,Youden’s index was 0.80,0.87 and 0.67 respectively.Conclusion The level of AFP in serum is an important index of diagnostic serology for Budd -Chiari syndrome complicated by hepatocellular carcinoma.The efficacy of diagnosis is the best when the cutoff value of AFP was set at 300 ng/ml.