CAJ | 학술논문

目的：探讨神经节苷脂联合依达拉奉治疗一氧化碳中毒迟发型脑病的临床疗效。方法：将本科收治的87例一氧化碳中毒迟发性脑病患者随机分为对照组（n=42）及试验组（n=45），两组均接受高压氧、抗血小板聚集、改善微循环、促进脑代谢等常规治疗；试验组在此基础上加用神经节苷脂及依达拉奉治疗，观察两组患者的治疗效果，采用简易智力状态量表（MMSE）和改良Barthel指数（MBI）量表评价两组患者治疗前、后的认知功能和日常生活活动能力。结果：对照组治疗总有效率为76.2%，试验组为93.3%，差异有统计学意义（P<0.05）。与治疗前相比，两组治疗后的MMSE评分、MBI评分均明显提高（P<0.05）；与治疗后的对照组相比，试验组治疗后MMSE评分、MBI评分也有明显提高（P<0.05）。结论：神经节苷脂联合依达拉奉治疗一氧化碳中毒迟发型脑病，可明显改善患者的预后，并明显改善患者的认知能力和日常生活能力。
목적：탐토신경절감지연합의체랍봉치료일양화탄중독지발형뇌병적림상료효。방법：장본과수치적87례일양화탄중독지발성뇌병환자수궤분위대조조（n=42）급시험조（n=45），량조균접수고압양、항혈소판취집、개선미순배、촉진뇌대사등상규치료；시험조재차기출상가용신경절감지급의체랍봉치료，관찰량조환자적치료효과，채용간역지력상태량표（MMSE）화개량Barthel지수（MBI）량표평개량조환자치료전、후적인지공능화일상생활활동능력。결과：대조조치료총유효솔위76.2%，시험조위93.3%，차이유통계학의의（P<0.05）。여치료전상비，량조치료후적MMSE평분、MBI평분균명현제고（P<0.05）；여치료후적대조조상비，시험조치료후MMSE평분、MBI평분야유명현제고（P<0.05）。결론：신경절감지연합의체랍봉치료일양화탄중독지발형뇌병，가명현개선환자적예후，병명현개선환자적인지능력화일상생활능력。
Objective:To study the efficiency of Ganglioside plus Edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning.Method:87 cases of delayed encephalopathy caused by carbon monoxide poisoning admitted to our department, were randomly divided into two groups:the control group( n=42) was given conventional hyperbaric oxygen,preventing platelet aggregation,improving microcirculation,improving cerebral metabolism and other conventional treatment;the experimental group( n=45) was given Ganglioside( 100 mg, intravenous drip 1/d), Edaravone( 30 mg, intravenous drip 2 /d) for 21 days on the basis of the control group. The efficiency of two groups were observed and their cognitive function and daily life activity with the mini-mental state examination( MMSE) and modified Barthel index( MBI) before treatment and after treatment were evaluated.Result:The efficiency of the control group was 76.2%, the efficiency of the experimental group was 93.3%(P<0.05). MMSE score and MBI score of the control group and experimental group after treatment were higher than those of before treatment(P<0.05);MMSE score and MBI score of the experimental group were obviously higher than those of the control group after treatment (P<0.05).Conclusion:Application of Ganglioside plus Edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning can obviously improve the prognosis of delayed encephalopathy, and significantly improve the patients’ cognitive ability and daily life ability.