CAJ | 학술논문

采用层层自组装法，以氧化硅微球为模板制备了壳聚糖（CS）／氧化石墨烯（GO）微球，去核后成功地制备了CS／G O 中空微胶囊。研究了组装次数、壳聚糖浓度和交联剂京尼平对微球及中空微胶囊形貌的影响，并以布洛芬为药物模型研究了CS／G O 中空微胶囊的载药性能及药物缓释性能。实验结果表明， CS／G O中空微胶囊具有完整的中空结构，粒径在760 n m左右。增加包裹层数和提高包裹溶液中的壳聚糖浓度都可以增加囊壁的厚度。经交联处理后， CS／G O微胶囊的囊壁更加致密和完整，其对布洛芬的载药率从19％提高至72％，释药时间从10 h延长至60 h。
채용층층자조장법，이양화규미구위모판제비료각취당（CS）／양화석묵희（GO）미구，거핵후성공지제비료CS／G O 중공미효낭。연구료조장차수、각취당농도화교련제경니평대미구급중공미효낭형모적영향，병이포락분위약물모형연구료CS／G O 중공미효낭적재약성능급약물완석성능。실험결과표명， CS／G O중공미효낭구유완정적중공결구，립경재760 n m좌우。증가포과층수화제고포과용액중적각취당농도도가이증가낭벽적후도。경교련처리후， CS／G O미효낭적낭벽경가치밀화완정，기대포락분적재약솔종19％제고지72％，석약시간종10 h연장지60 h。
The graphene oxide (GO)/chitosan (CS) microcapsules were prepared by using the layer by layer (LbL) self‐assembly method using SiO2 template .Oncentration ,layers and crosslinking agent were studied in this paper .Ibuprofen was used as model drug to study the drug loading and drug release properties of CS/GO microcapsules .The results show that the GO/CS microcapsules have spherical structure ,and the microcapsules are monodispersed with the diameter of 760 nm .The thickness of microcapsule wall increases with bilayers and CS concentration increased .Crosslinking process can not only improve the morphology of microcapsules ,but al‐so can slightly improve the drug loading ratio from 19% to 72% and length the drug release time from 10 to 60 h .