临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
Journal of Clinical and Experimental Medicine
2015年
17期
1474-1476
,共3页
小儿%慢性咳嗽%妥洛特罗%布地奈德
小兒%慢性咳嗽%妥洛特囉%佈地奈德
소인%만성해수%타락특라%포지내덕
Children%Chronic cough%Tulobuterol%Budesonide
目的：探讨妥洛特罗贴剂联合布地奈德雾化治疗小儿慢性咳嗽的疗效及其作用机制。方法选取60例慢性咳嗽患儿，随机分为观察组和对照组，每组30例。对照组仅给予布地奈德雾化治疗，观察组采用妥洛特罗贴剂联合布地奈德雾化治疗。比较两组患者临床疗效、咳嗽症状评分及外周血炎症指标。结果治疗后，观察组患儿咳嗽症状评分显著低于对照组（0.54±0.28 vs.1.16±0.26），差异具有统计学意义（ t =2.853，P <0.05）。观察组临床总有效率显著优于对照组（93.3% vs.73.3%），差异具有统计学意义（χ2=4.320，P <0.05）。观察组患儿外周血嗜酸性粒细胞（Eos）计数、肿瘤坏死因子-α（TNF-α）、白介素-5（IL-5）均明显低于对照组，差异具有统计学意义（ P <0.05）。结论妥洛特罗贴剂联合布地奈德雾化吸入小儿慢性咳嗽，与单用地奈德雾化吸入治疗相比较，临床疗效更优，其作用机制可能是通过有效抑制炎症细胞、炎症因子及介质的释放来发挥协同作用。
目的：探討妥洛特囉貼劑聯閤佈地奈德霧化治療小兒慢性咳嗽的療效及其作用機製。方法選取60例慢性咳嗽患兒，隨機分為觀察組和對照組，每組30例。對照組僅給予佈地奈德霧化治療，觀察組採用妥洛特囉貼劑聯閤佈地奈德霧化治療。比較兩組患者臨床療效、咳嗽癥狀評分及外週血炎癥指標。結果治療後，觀察組患兒咳嗽癥狀評分顯著低于對照組（0.54±0.28 vs.1.16±0.26），差異具有統計學意義（ t =2.853，P <0.05）。觀察組臨床總有效率顯著優于對照組（93.3% vs.73.3%），差異具有統計學意義（χ2=4.320，P <0.05）。觀察組患兒外週血嗜痠性粒細胞（Eos）計數、腫瘤壞死因子-α（TNF-α）、白介素-5（IL-5）均明顯低于對照組，差異具有統計學意義（ P <0.05）。結論妥洛特囉貼劑聯閤佈地奈德霧化吸入小兒慢性咳嗽，與單用地奈德霧化吸入治療相比較，臨床療效更優，其作用機製可能是通過有效抑製炎癥細胞、炎癥因子及介質的釋放來髮揮協同作用。
목적：탐토타락특라첩제연합포지내덕무화치료소인만성해수적료효급기작용궤제。방법선취60례만성해수환인，수궤분위관찰조화대조조，매조30례。대조조부급여포지내덕무화치료，관찰조채용타락특라첩제연합포지내덕무화치료。비교량조환자림상료효、해수증상평분급외주혈염증지표。결과치료후，관찰조환인해수증상평분현저저우대조조（0.54±0.28 vs.1.16±0.26），차이구유통계학의의（ t =2.853，P <0.05）。관찰조림상총유효솔현저우우대조조（93.3% vs.73.3%），차이구유통계학의의（χ2=4.320，P <0.05）。관찰조환인외주혈기산성립세포（Eos）계수、종류배사인자-α（TNF-α）、백개소-5（IL-5）균명현저우대조조，차이구유통계학의의（ P <0.05）。결론타락특라첩제연합포지내덕무화흡입소인만성해수，여단용지내덕무화흡입치료상비교，림상료효경우，기작용궤제가능시통과유효억제염증세포、염증인자급개질적석방래발휘협동작용。
Objective To evaluate the efficacy and mechanism of tulobuterol tape combined with budesonide atomization inhalation in treatment for children chronic cough. Methods 60 children of chronic cough were randomly divided into control group and observation group,30 cases in each group. Tulobuterol tape combined with budesonide atomization inhalation were used in observation group and budesonide atomization inhalation alone was used in control group. The clinical efficacy,cough symptom scores and peripheral inflammation index were compared between the two groups. Results After treatment,the cough symptom scores in observation group and control group respectively was(0. 54 ± 0. 28)points and(1. 16 ± 0. 26)points. The points of observation group was significantly lower than control group,showed significant differences between the two groups( t =2. 853,P <0. 05). The clinical efficacy was 93. 3% in observation group,as compared with those of 73. 3% in control group, which showed significant differences between the two groups(χ2 =4. 320,P <0. 05). The ECP,Eos,TNF-αand IL-5 of peripheral blood in observation group was lower than those in control group( P <0. 05). Conclusion Tulobuterol patch budesonide inhalation as the treatment of chronic cough in children showed clinical better efficacy compared to budesonide inhalation therapy. And its mechanism may be effectively sup-pressed by inflammatory cells,inflammatory cytokines and media releasing of synergies.
