CAJ | 학술논문

目的：观察分析右美托咪定对非体外循环冠状动脉旁路移植术（OPCAB）患者心肌损伤的影响。方法选择择期行OPCAB患者88例，随机分为观察组和对照组两组，每组44例，观察组麻醉诱导后给予右美托咪定直至术毕，对照组采用等容量生理盐水。结果观察组T4时SVI及LVSWI均升高，T3和T4时SVR降低，差异有统计学意义（P＜0.05），但均为正常范围，其余指标差异无统计学意义（P＞0.05）；观察组T4时SVI和LVSWI均显著升高（P＜0.05）；对照组血液动力学指标在各时点均无差异性（P＞0.05）；观察组各时点cTnI浓度低于对照组，差异有统计学意义（P＜0.05）。结论右美托咪定可以显著降低OPCAB患者的心肌损伤。
목적：관찰분석우미탁미정대비체외순배관상동맥방로이식술（OPCAB）환자심기손상적영향。방법선택택기행OPCAB환자88례，수궤분위관찰조화대조조량조，매조44례，관찰조마취유도후급여우미탁미정직지술필，대조조채용등용량생리염수。결과관찰조T4시SVI급LVSWI균승고，T3화T4시SVR강저，차이유통계학의의（P＜0.05），단균위정상범위，기여지표차이무통계학의의（P＞0.05）；관찰조T4시SVI화LVSWI균현저승고（P＜0.05）；대조조혈액동역학지표재각시점균무차이성（P＞0.05）；관찰조각시점cTnI농도저우대조조，차이유통계학의의（P＜0.05）。결론우미탁미정가이현저강저OPCAB환자적심기손상。
Objective To observe and analysis of dexmedetomidine on the effect of myocardial damage in patients undergoing non extracorporeal circulation coronary artery bypass graft surgery (OPCAB). Methods 88 patients undergoing OPCAB were selected randomly divided into two groups, the observation group and the control group, 44 cases in each group, the observation group after induction of anesthesia give dexmedetomidine until the completion of surgery and control group with the volume of normal saline. Results The observation group T4 SVI and LVSWI increased, T3 and T4 SVR decreased, the difference is statistically significant (P<0.05), but are in the normal range, other targets were no statistical significance (P>0.05), observation group T4 SVI and LVSWI increased signiifcantly (P<0.05), control group, blood dynamic mechanics index had no difference at each time point (P>0.05), observation group at each time point cTnI concentration was significantly lower than that of the control group, the difference is statistically significant (P<0.05). Conclusion Dexmedetomidine can signiifcantly reduce myocardial injury in patients with OPCAB.