CAJ | 학술논문

目的：探讨曲美他嗪对老年慢性心力衰竭患者心率变异性影响。方法选择42例老年慢性心力衰竭患者，研究组在对照组传统治疗方法的基础上加用曲美他嗪，于治疗前及治疗后12周对患者心率、射血分数（ EF）、6 min步行试验和HRV进行检测，比较检测结果。结果两组心率、EF、6 min步行试验在治疗前均无统计学差异，治疗后研究组心率显著低于对照组，EF和6-MWD显著高于对照组。两组HRV指标治疗前均无统计学差异，治疗后两组的各项指标均出现显著提升，治疗后研究组SDNN、SDANN、rMSSD、pNN50显著高于对照组。结论在常规治疗基础上加用曲美他嗪对老年慢性心力衰竭患者能明显改善HRV与心功能，值得临床应用。
목적：탐토곡미타진대노년만성심력쇠갈환자심솔변이성영향。방법선택42례노년만성심력쇠갈환자，연구조재대조조전통치료방법적기출상가용곡미타진，우치료전급치료후12주대환자심솔、사혈분수（ EF）、6 min보행시험화HRV진행검측，비교검측결과。결과량조심솔、EF、6 min보행시험재치료전균무통계학차이，치료후연구조심솔현저저우대조조，EF화6-MWD현저고우대조조。량조HRV지표치료전균무통계학차이，치료후량조적각항지표균출현현저제승，치료후연구조SDNN、SDANN、rMSSD、pNN50현저고우대조조。결론재상규치료기출상가용곡미타진대노년만성심력쇠갈환자능명현개선HRV여심공능，치득림상응용。
Objective To investigate the effect of trimetazidine on heart rate variability( HRV)in elderly patients with chronic heart fail-ure( CHF). Methods Forty-two elderly patients with CHF were collected and divided into study group and control group. The patients in con-trol group received conventional treatment;in addition to conventional treatment,the patients in study group received trimetazidine. Before and af-ter 12 weeks of treatment,heart rate,ejection fraction(EF),6 min walk test(6-MWD)and HRV testing were taken in all patients and the test results were compared between two groups. Results Heart rate,EF and 6 -MWD were not statistically different before treatment between two groups. However,heart rate was significantly lower,EF,and 6-MWD were significantly higher than the control group after treatment. HRV were not statistically different before treatment,but after treatment the indicators significantly improved in both groups. After treatment in the study group,SDNN,SDANN,rMSSD,and pNN50 were significantly higher. Conclusion The conventional therapy combined with trimetazidine in elderly CHF patients can significantly improve HRV and heart function.