CAJ | 학술논문

目的：通过检测Survivin和P53在乳腺癌组织及正常乳腺组织中的表达情况，从而探讨两者与乳腺癌发生发展的关系。方法采用免疫组化SP方法检测乳腺癌组织及正常乳腺组织中Survivin和P53的表达情况，比较Sur-vivin和P53在两种不同组织中的表达情况。结果乳腺癌组织中，Survivin的表达阳性率为76.0%（38/50），在正常乳腺组织中Survivin的表达阳性率为10.0%（2/20），Survivin在乳腺癌组织表达阳性率高于正常乳腺组织，差异有显著性（ P <0.05）。P53在乳腺癌组织中的表达阳性率为78.0%（39/50），在正常乳腺中的阳性表达率为15.0%（3/20），P53在乳腺癌组织表达阳性率高于正常乳腺组织，差异有显著性（ P <0.05）。Survivin的表达水平与乳腺癌分化程度、浸润深度、淋巴结转移无明显相关；但是P53与乳腺癌分化程度、淋巴结转移明显相关。结论 Survivin与P53与乳腺癌的发生及发展密切相关，检测Survivin与P53的表达水平可以作为辅助诊断乳腺癌的标准，同时检测P53的表达水平可以预测乳腺癌患者预后情况。
목적：통과검측Survivin화P53재유선암조직급정상유선조직중적표체정황，종이탐토량자여유선암발생발전적관계。방법채용면역조화SP방법검측유선암조직급정상유선조직중Survivin화P53적표체정황，비교Sur-vivin화P53재량충불동조직중적표체정황。결과유선암조직중，Survivin적표체양성솔위76.0%（38/50），재정상유선조직중Survivin적표체양성솔위10.0%（2/20），Survivin재유선암조직표체양성솔고우정상유선조직，차이유현저성（ P <0.05）。P53재유선암조직중적표체양성솔위78.0%（39/50），재정상유선중적양성표체솔위15.0%（3/20），P53재유선암조직표체양성솔고우정상유선조직，차이유현저성（ P <0.05）。Survivin적표체수평여유선암분화정도、침윤심도、림파결전이무명현상관；단시P53여유선암분화정도、림파결전이명현상관。결론 Survivin여P53여유선암적발생급발전밀절상관，검측Survivin여P53적표체수평가이작위보조진단유선암적표준，동시검측P53적표체수평가이예측유선암환자예후정황。
Objective By detecting Survivin and P53 in breast cancer and normal breast tissues,and thereby to explore the relationship between the occurrence of breast cancer development. Methods SP immunohistochemical method to detect cases by comparing their expression in breast cancer tissue and normal breast tissue expression both in two different tissues. Results Survivin expression positive rate in breast cancer was 76. 0%(38/50). Survivin expression positive rate in normal breast tissue was 10. 0%(2/20). The positive rate of Survivin expression in breast cancer was higher than in normal breast tissue. There was significantly difference( P <0. 05). The positive rate of P53 expression in breast cancer was 78. 0%(39/50),the positive rate of P53 expression in normal gastric mucosa was 15. 0%(3/20). The positive rate of P53 expres-sion in breast cancer was higher than in normal breast tissue. There was significantly difference( P <0. 05). Survivin expression levels with the degree of differentiation of in breast cancer,lymph node metastasis was no significant correlation;but P53 degree of differentiation of breast canc-er,depth of invasion,lymph node metastasis was significantly correlated. Conclusion Survivin and P53 was closely related to the occurrence and development of breast cancer. By detecting the expression level of Survivin and P53 can be used as a standard diagnosis of breast cancer. Detecting the expression level of P53 can predict the prognosis of breast cancer patients.