CAJ | 학술논문

microRNA是一类内生的、长约22个核苷酸左右的非编码小分子RNA，主要通过结合其靶基因的3′UTR（非翻译区），从而降解靶基因mRNA或抑制其蛋白翻译。microRNA通过基因切割和翻译抑制的方式直接调控基因组中30％以上的蛋白编码基因表达。银屑病以过度增殖和异常分化的角质形成细胞为显著特征，角质形成细胞的上述病理改变被认为起始于细胞免疫系统，T细胞、树突细胞和多种免疫相关细胞因子均牵涉其中。而microRNA几乎参与上述整个病理过程，并发挥重要作用。且microRNA表达的特异性和时序性与证候的动态时空特性极其相似。将microRNA引入银屑病中医证候研究，为从转录后水平阐明银屑病中医证候实质提供新的视角。
microRNA시일류내생적、장약22개핵감산좌우적비편마소분자RNA，주요통과결합기파기인적3′UTR（비번역구），종이강해파기인mRNA혹억제기단백번역。microRNA통과기인절할화번역억제적방식직접조공기인조중30％이상적단백편마기인표체。은설병이과도증식화이상분화적각질형성세포위현저특정，각질형성세포적상술병리개변피인위기시우세포면역계통，T세포、수돌세포화다충면역상관세포인자균견섭기중。이microRNA궤호삼여상술정개병리과정，병발휘중요작용。차microRNA표체적특이성화시서성여증후적동태시공특성겁기상사。장microRNA인입은설병중의증후연구，위종전록후수평천명은설병중의증후실질제공신적시각。
MicroRNAisasmallnon-codingendogenousRNAmoleculewhichisconsistedofapproximately22nucleotides.Itde-generate target gene mRNA or suppress its protein translation through integration with the 3’UTR of the target gene.MicroRNA reg-ulates over 30%of protein coding genetic expression of the genome by cleavage and translation suppression.Keratinocyte cell pro-liferation and abnormal differentiation are the key characteristics of psoriasis,and these pathological changes are thought to origi-nate from cell immune system.T cell,dendritic cell and multiple immune-related cell factors were all involved.MicroRNA partici-pates in throughout the pathological process and plays an important role.MicroRNA expression specificity and sequence shows great similarity with the temporal-spatial characteristic of the syndrome.Introducing mircoRNA into psoriasis TCM syndrome re-search provides a new aspect to the topic through the interpretation of post-transcriptional level.