CAJ | 학술논문

目的：收集2014年12月之前国内国外发表的关于康艾注射液姑息治疗晚期恶性肿瘤的随机对照试验文献，利用系统评价的方法评价康艾注射液在晚期恶性肿瘤姑息治疗中的疗效和安全性。方法：全面检索 MEDLINE（Pubmed）、Co-chrane library、中国生物医学文献数据库（CBM）、维普中文科技期刊数据库（VIP）、中国期刊全文数据库（CNKI）、万方数据库以得到康艾注射液姑息治疗晚期恶性肿瘤的合适文献，并采用 Cochrane 协作网提供的 RevMan 5．2软件对数据进行处理。结果：共纳入8个 RCT，545例，文献质量均较低。对 KPS 评分改善情况进行 meta 分析，异质性检验（χ2＝12．12，P＝0．06，I2＝51％），采用随机效应模型统计分析，治疗组优于对照组（RR ＝2．69，Z ＝4．54，P ＜0．00001，95％CI ＝[1．75，4．12]）；采用描述性统计方法分析，改善纳差症状方面共有4个研究，其中3个研究提示治疗组优于对照组。减轻疼痛方面共纳入6个试验，其中4个试验提示康艾注射液有利于减轻癌痛。康艾注射液姑息治疗在改善乏力症状和改善睡眠方面，结果均提示优于对照组。结论：康艾注射液在姑息治疗晚期恶性肿瘤方面，能够改善患者纳差、癌痛、乏力、失眠不适症状，并提高患者生活质量，但因纳入文献质量较低，需要更多更规范的 RCT 予以进一步印证。
목적：수집2014년12월지전국내국외발표적관우강애주사액고식치료만기악성종류적수궤대조시험문헌，이용계통평개적방법평개강애주사액재만기악성종류고식치료중적료효화안전성。방법：전면검색 MEDLINE（Pubmed）、Co-chrane library、중국생물의학문헌수거고（CBM）、유보중문과기기간수거고（VIP）、중국기간전문수거고（CNKI）、만방수거고이득도강애주사액고식치료만기악성종류적합괄문헌，병채용 Cochrane 협작망제공적 RevMan 5．2연건대수거진행처리。결과：공납입8개 RCT，545례，문헌질량균교저。대 KPS 평분개선정황진행 meta 분석，이질성검험（χ2＝12．12，P＝0．06，I2＝51％），채용수궤효응모형통계분석，치료조우우대조조（RR ＝2．69，Z ＝4．54，P ＜0．00001，95％CI ＝[1．75，4．12]）；채용묘술성통계방법분석，개선납차증상방면공유4개연구，기중3개연구제시치료조우우대조조。감경동통방면공납입6개시험，기중4개시험제시강애주사액유리우감경암통。강애주사액고식치료재개선핍력증상화개선수면방면，결과균제시우우대조조。결론：강애주사액재고식치료만기악성종류방면，능구개선환자납차、암통、핍력、실면불괄증상，병제고환자생활질량，단인납입문헌질량교저，수요경다경규범적 RCT 여이진일보인증。
Objective:To collect literature with Randomized Control Trials (RCTs)which were published before December 201 4, using system evaluation to assess the efficacy and safety of Kang Ai Injection in palliative treatment of advanced malignant tumors. Methods:Electronic database such as MEDLINE (Pubmed),Cochrane library,CBM,VIP,CNKI,Wanfang were searched through to collect appropriate studies about Kang Ai Injection combined with best supportive care (BSC)versus BSC alone in the palliative treatment of advanced tumors.All data were analyzed and processed by RevMan5.2 software provided by Cochrane.Re-sults:Eight RCTs,including 545 cases were involved into the study,but all of the studies were of low quality.The patients`im-provement of KPS was evaluated by meta-analysis.Heterogeneity text indicated data (χ2 =1 2.1 2,P =0.06,I2 =51 %).The re-sults with random effects model showed that Kang Ai Injection could improve KPS (RR =2.69,Z =4.54,P <0.00001 ,95%CI =[1 .75,4.1 2]).The improvement of the symptoms were analyzed by the method of descriptive statistics.All in all,three of four studies included indicated that Kang Ai Injection could improve the symptom of poor appetite in a larger deal.Four in six studies included showed that Kang Ai Injection could alleviate the pain in a larger amount.Meanwhile,all studies included indicated that Kang Ai Injection could better improve the symptoms of fatigue and insomnia compared with the control group.Conclusion:Adop-ting Kang Ai Injection in the palliative treatment of malignant tumors can improve the’symptoms of poor appetite,cancer pain,fa-tigue and insomnia as well as the quality of life.However,because of the low qualities of the studies,the results should be further proved by more normative RCTs.