CAJ | 학술논문

目的：观察奈达铂对食管癌患者的临床治疗效果。方法将64例食管癌患者随机分为治疗组和对照组各32例。治疗组采取奈达铂联合5-氟尿嘧啶（5-FU）进行治疗，对照组采取顺铂（DDP）联合5-FU 进行治疗，21d为1个疗程，连用2个疗程。对比2组患者治疗的总有效率、不良反应的发生率以。结果治疗组的总有效率为53.1％，恶心呕吐的发生率为21.9％，肾功能异常的发生率为12.5％；对照组则分别为28.1％、46.9％及34.4％。2组比较，治疗的总有效率、恶心呕吐的发生率以及肾功能异常的发生率差异均有统计学意义（ P ﹤0.05），其他不良反应无明显差异。结论奈达铂联合5-FU 治疗食管癌可显著提高治疗的总有效率，不良反应小，值得临床上推广使用。
목적：관찰내체박대식관암환자적림상치료효과。방법장64례식관암환자수궤분위치료조화대조조각32례。치료조채취내체박연합5-불뇨밀정（5-FU）진행치료，대조조채취순박（DDP）연합5-FU 진행치료，21d위1개료정，련용2개료정。대비2조환자치료적총유효솔、불량반응적발생솔이。결과치료조적총유효솔위53.1％，악심구토적발생솔위21.9％，신공능이상적발생솔위12.5％；대조조칙분별위28.1％、46.9％급34.4％。2조비교，치료적총유효솔、악심구토적발생솔이급신공능이상적발생솔차이균유통계학의의（ P ﹤0.05），기타불량반응무명현차이。결론내체박연합5-FU 치료식관암가현저제고치료적총유효솔，불량반응소，치득림상상추엄사용。
Objective To observe the efficacy of nedaplatin in treatment of esophageal cancers. Methods 64 cases of esophageal cancer patients were randomly divided into treatment group and contorl group,32 cases of each group. Treatment group received nedaplatin combined with 5-fluorouracil for treatment,Contorl group were treated with cisplatin and 5-fluoroura-cil,21 days for a course of treatment,All were treated for two cycles,then the total effective rate and incidences of adverse reac-tions were compared between two groups. Results The total effective rate、the incidence of nausea and vomiting and kidney dysfunction of the treatment group were 53. 1% ,21. 9% and 12. 5% ,the contorl group were 28. 1% ,46. 9% and 34. 4% ,re-spectively. The total effective rate、the incidence of nausea and vomiting and kidney dysfunction between the two groups were different and no significant difference in other adverse reactions. Conclusion Nedaplatin combined with 5-fluorouracil in treatment of esophageal cancers could significantly increase the total effective rate and presented no negative influenc on the postoperative complication rate.