山东医药
山東醫藥
산동의약
Shandong Medical Journal
2015年
35期
5-7
,共3页
中性粒细胞%淋巴细胞%红细胞分布宽度%肝炎%乙型肝炎
中性粒細胞%淋巴細胞%紅細胞分佈寬度%肝炎%乙型肝炎
중성립세포%림파세포%홍세포분포관도%간염%을형간염
neutrophil%lymphocytes%red blood cell distribution width%hepatitis%hepatitis B
目的：观察乙型肝炎患者外周血中性粒细胞与淋巴细胞比值（ NLR）、红细胞分布宽度（ RDW）变化，并探讨其意义。方法82例乙型肝炎患者按病情分为慢性乙型肝炎患者42例（A组）、慢性重型肝炎患者40例[B组，根据B组患者的NLR中位数（3．51）分为B1组（NLR≤3．51）和B2组（NLR＞3．51）各20例]，另选45例健康体检者作为对照（C组）。使用希森美康XE-5000型血常规分析仪检测各组外周血中红细胞（ RBC）、血红蛋白（ Hb）、RDW、中性粒细胞的绝对数目和淋巴细胞的绝对数目，计算NLR。使用法国STAGO全自动血凝仪，采用凝固法检测凝血酶原活动度（PTA）。结果与C组比较，A组RDW升高，RBC、Hb降低（P均＜0．05）；与C组比较， B组RDW、NLR升高，RBC、Hb降低（ P均＜0．05）；与A组比较，B组RDW、NLR升高，PTA、RBC、Hb降低（ P均＜0．05）。82例乙型肝炎患者中PTA与NLR呈负相关（r＝－0．5571，P＜0．5）。与B2组比较，B1组NLR降低，年龄减小（P均＜0．05）。结论乙型肝炎患者NLR、RDW升高，检测两指标有助于肝病病情严重程度和肝脏损害程度的判断。
目的：觀察乙型肝炎患者外週血中性粒細胞與淋巴細胞比值（ NLR）、紅細胞分佈寬度（ RDW）變化，併探討其意義。方法82例乙型肝炎患者按病情分為慢性乙型肝炎患者42例（A組）、慢性重型肝炎患者40例[B組，根據B組患者的NLR中位數（3．51）分為B1組（NLR≤3．51）和B2組（NLR＞3．51）各20例]，另選45例健康體檢者作為對照（C組）。使用希森美康XE-5000型血常規分析儀檢測各組外週血中紅細胞（ RBC）、血紅蛋白（ Hb）、RDW、中性粒細胞的絕對數目和淋巴細胞的絕對數目，計算NLR。使用法國STAGO全自動血凝儀，採用凝固法檢測凝血酶原活動度（PTA）。結果與C組比較，A組RDW升高，RBC、Hb降低（P均＜0．05）；與C組比較， B組RDW、NLR升高，RBC、Hb降低（ P均＜0．05）；與A組比較，B組RDW、NLR升高，PTA、RBC、Hb降低（ P均＜0．05）。82例乙型肝炎患者中PTA與NLR呈負相關（r＝－0．5571，P＜0．5）。與B2組比較，B1組NLR降低，年齡減小（P均＜0．05）。結論乙型肝炎患者NLR、RDW升高，檢測兩指標有助于肝病病情嚴重程度和肝髒損害程度的判斷。
목적：관찰을형간염환자외주혈중성립세포여림파세포비치（ NLR）、홍세포분포관도（ RDW）변화，병탐토기의의。방법82례을형간염환자안병정분위만성을형간염환자42례（A조）、만성중형간염환자40례[B조，근거B조환자적NLR중위수（3．51）분위B1조（NLR≤3．51）화B2조（NLR＞3．51）각20례]，령선45례건강체검자작위대조（C조）。사용희삼미강XE-5000형혈상규분석의검측각조외주혈중홍세포（ RBC）、혈홍단백（ Hb）、RDW、중성립세포적절대수목화림파세포적절대수목，계산NLR。사용법국STAGO전자동혈응의，채용응고법검측응혈매원활동도（PTA）。결과여C조비교，A조RDW승고，RBC、Hb강저（P균＜0．05）；여C조비교， B조RDW、NLR승고，RBC、Hb강저（ P균＜0．05）；여A조비교，B조RDW、NLR승고，PTA、RBC、Hb강저（ P균＜0．05）。82례을형간염환자중PTA여NLR정부상관（r＝－0．5571，P＜0．5）。여B2조비교，B1조NLR강저，년령감소（P균＜0．05）。결론을형간염환자NLR、RDW승고，검측량지표유조우간병병정엄중정도화간장손해정도적판단。
Objective To observe the changes of neutrophil-lymphocyte ratio ( NLR) and red blood cell distribution width (RDW) in the peripheral blood of hepatitis B virus (HBV)-infected patients and to investigate the significance. Methods Fouty-tow patients with chronic hepatitis B (CHB, group A), 40 patients with chronic severe hepatitis B ( CSHB, group B) and 45 normal healthy persons ( control group, group C) were enrolled in this study.According to me-dian value of NLR, group B was divided into two groups:group B1 including 20 patients ( NLR≤3.51) and group B2 in-cluding 20 patients (NLR>3.51).In all subjects, a blood sample was collected at admission to examine RBC, Hb, RDW, NLR and prothrombin activity ( PTA) , which were determined using XE-5000 automated hematology analyzer and STAGO STA-R automatic coagulation analyzer.Results Compared with group C, RDW was increased, and RBC and Hb were decreased in the group A ( all P<0.05);compared with group C, RDW and NLR were increased, and RBC and Hb were decreased in the group B (all P<0.05);compared with group A, RDW and NLR were increased and PTA,RBC and Hb were decreased in the group B;and statistical difference was found (all P<0.05).Moreover, the NLR level was nega-tively correlated with PTA (r=-0.5571, P<0.5).Patients in group B2 tended to be older, and had higher NLR values as compared with those of group B1 (all P<0.05).Conclusion RDW and NLR values are increased in patients with hepatitis B and the combined detection of them helps to determine the severity and degree of liver damage.
