世界中医药
世界中醫藥
세계중의약
World Chinese Medicine
2015年
8期
1254-1256,1260
,共4页
中医药%高尿酸血症%系统评价
中醫藥%高尿痠血癥%繫統評價
중의약%고뇨산혈증%계통평개
Chinese Medicine%Hyperuricemia%Systematic Review
目的:以循证医学系统评价为依据,对中药治疗高尿酸血症的临床疗效做出较客观的评估。方法:计算机检索国内医学期刊杂志(1980—2014年),选择中医药治疗高尿酸血症的随机对照试验研究进行 Meta 分析。结果:10篇文献进入Meta 分析,总病例数为1000例。Meta 分析显示与常规化学相比,中药组治疗高尿酸血症总有效率存在差异具有统计学意义(P =0.16,[OR =2.58,95%CI(1.58,4.21)]),降低血尿酸水平的 Meta 分析显示:[SMD =SMD =-0.58,95%CI(-0.90,-0.26),Z =3.53,(P =0.0004)],治疗组与对照组差异有统计学意义。结论:中医治疗组对高尿酸血症的总临床疗效及降低血尿酸水平方面与化学药对照组相比更优。本文受原始研究质量等因素的影响,研究结果存在一定局限性,期待开展更多大样本高质量的临床研究加以验证。
目的:以循證醫學繫統評價為依據,對中藥治療高尿痠血癥的臨床療效做齣較客觀的評估。方法:計算機檢索國內醫學期刊雜誌(1980—2014年),選擇中醫藥治療高尿痠血癥的隨機對照試驗研究進行 Meta 分析。結果:10篇文獻進入Meta 分析,總病例數為1000例。Meta 分析顯示與常規化學相比,中藥組治療高尿痠血癥總有效率存在差異具有統計學意義(P =0.16,[OR =2.58,95%CI(1.58,4.21)]),降低血尿痠水平的 Meta 分析顯示:[SMD =SMD =-0.58,95%CI(-0.90,-0.26),Z =3.53,(P =0.0004)],治療組與對照組差異有統計學意義。結論:中醫治療組對高尿痠血癥的總臨床療效及降低血尿痠水平方麵與化學藥對照組相比更優。本文受原始研究質量等因素的影響,研究結果存在一定跼限性,期待開展更多大樣本高質量的臨床研究加以驗證。
목적:이순증의학계통평개위의거,대중약치료고뇨산혈증적림상료효주출교객관적평고。방법:계산궤검색국내의학기간잡지(1980—2014년),선택중의약치료고뇨산혈증적수궤대조시험연구진행 Meta 분석。결과:10편문헌진입Meta 분석,총병례수위1000례。Meta 분석현시여상규화학상비,중약조치료고뇨산혈증총유효솔존재차이구유통계학의의(P =0.16,[OR =2.58,95%CI(1.58,4.21)]),강저혈뇨산수평적 Meta 분석현시:[SMD =SMD =-0.58,95%CI(-0.90,-0.26),Z =3.53,(P =0.0004)],치료조여대조조차이유통계학의의。결론:중의치료조대고뇨산혈증적총림상료효급강저혈뇨산수평방면여화학약대조조상비경우。본문수원시연구질량등인소적영향,연구결과존재일정국한성,기대개전경다대양본고질량적림상연구가이험증。
Objective:Using evidence-based medicine system to make an impersonal evaluation on the validity of Chinese medi-cine in the treatment of hyperuricemia.Methods:Randomized controlled trials(RCT)on Chinese medicine’s efficacy on treating hyperruricemia were retrieved from domestic medicinal journals (1 980 -201 4)and then were evaluated through meta-analysis. Results:Ten studies involved 1 000 patients were identified.The results showed that there was significant difference between using Chinese medicine and routine chemical to treat hyperruricemia:(P =0.1 6,[OR =2.58,95%CI (1 .58,4.21 )]).The meta-a-nalysis result of reducing the level of blood uric acid was [SMD =SMD =-0.58,95%CI(-0.90,-0.26),Z =3.53,(P =0. 0004)].The differences between treatment group and control group were of statistical significance.Conclusion:In both the as-pects of total clinical efficacy and blood uric acid level reduction,the performance of treatment groups (using Chinese medicine) was better than the control groups (using chemical drugs).However,because some of the RCTs reviewed in this study did not ful-fill the strict requirement of evidence-based medicine,the results of this study can have deviation.Therefore,more qualified re-search with large sample were expected to evaluate these results.