山东医药
山東醫藥
산동의약
Shandong Medical Journal
2015年
35期
16-18
,共3页
刘士臣%申福国%杨建华%乔建民%季庆辉%崔宏宇%张富运
劉士臣%申福國%楊建華%喬建民%季慶輝%崔宏宇%張富運
류사신%신복국%양건화%교건민%계경휘%최굉우%장부운
脊髓损伤%高压氧%突触素Ⅰ
脊髓損傷%高壓氧%突觸素Ⅰ
척수손상%고압양%돌촉소Ⅰ
spinal cord injury%hyperbaric oxygen%synaptophysinⅠ
目的:观察高压氧(HBO)治疗对大鼠脊髓损伤(SCI)的治疗作用,并探讨其可能机制。方法25只健康清洁级成年SD大鼠随机分为SCI组10只、HBO组10只、对照组5只,SCI组、HBO组大鼠均制备SCI模型,HBO组制模成功后采用HBO治疗;对照组采取同前方法咬开椎板,不损伤脊髓,后给予缝合。观察两组大鼠不同时点(制模成功后6 h及1、3、7、14、21 d,分别计为T1、T2、T3、T4、T5、T6) BBB评分及脊髓组织中突触素Ⅰ mRNA。结果与对照组比较,HBO组、SCI组各时点( T3、T4、T5、T6) BBB评分及脊髓组织突触素Ⅰ mRNA表达升高( P均<0.05);与SCI 组比较,HBO组各时点(T3、T4、T5、T6)BBB 评分及脊髓组织突触素Ⅰ mRNA 表达升高(P 均<0.05)。结论 HBO可促进大鼠损伤脊髓的恢复,其机制可能与上调损伤脊髓组织内突触素ⅠmRNA表达有关。
目的:觀察高壓氧(HBO)治療對大鼠脊髓損傷(SCI)的治療作用,併探討其可能機製。方法25隻健康清潔級成年SD大鼠隨機分為SCI組10隻、HBO組10隻、對照組5隻,SCI組、HBO組大鼠均製備SCI模型,HBO組製模成功後採用HBO治療;對照組採取同前方法咬開椎闆,不損傷脊髓,後給予縫閤。觀察兩組大鼠不同時點(製模成功後6 h及1、3、7、14、21 d,分彆計為T1、T2、T3、T4、T5、T6) BBB評分及脊髓組織中突觸素Ⅰ mRNA。結果與對照組比較,HBO組、SCI組各時點( T3、T4、T5、T6) BBB評分及脊髓組織突觸素Ⅰ mRNA錶達升高( P均<0.05);與SCI 組比較,HBO組各時點(T3、T4、T5、T6)BBB 評分及脊髓組織突觸素Ⅰ mRNA 錶達升高(P 均<0.05)。結論 HBO可促進大鼠損傷脊髓的恢複,其機製可能與上調損傷脊髓組織內突觸素ⅠmRNA錶達有關。
목적:관찰고압양(HBO)치료대대서척수손상(SCI)적치료작용,병탐토기가능궤제。방법25지건강청길급성년SD대서수궤분위SCI조10지、HBO조10지、대조조5지,SCI조、HBO조대서균제비SCI모형,HBO조제모성공후채용HBO치료;대조조채취동전방법교개추판,불손상척수,후급여봉합。관찰량조대서불동시점(제모성공후6 h급1、3、7、14、21 d,분별계위T1、T2、T3、T4、T5、T6) BBB평분급척수조직중돌촉소Ⅰ mRNA。결과여대조조비교,HBO조、SCI조각시점( T3、T4、T5、T6) BBB평분급척수조직돌촉소Ⅰ mRNA표체승고( P균<0.05);여SCI 조비교,HBO조각시점(T3、T4、T5、T6)BBB 평분급척수조직돌촉소Ⅰ mRNA 표체승고(P 균<0.05)。결론 HBO가촉진대서손상척수적회복,기궤제가능여상조손상척수조직내돌촉소ⅠmRNA표체유관。
Objective To observe the therapeutic effect of hyperbaric oxygen ( HBO ) on the spinal cord injury ( SCI) , and to explore its possible mechanism.Methods Twenty-five healthy and clean SD adult rats were randomly di-vided into the SCI group (n=10), HBO group (n=10) and the control group (n=5).The SCI model rats were prepared in the SCI and HBO groups, after the success of molding, the HBO group received HBO treatment;the vertebral plates of rats in the control group were opened and sutured without damage to the spinal cord.BBB rating and synaptophysinⅠmR-NA in the spinal cord tissues at different time points (6 h after molding and 1, 3, 7, 14 and 21 d, which is counted as T1 , T2 , T3 , T4 , T5 and T6 ) were observed in the two groups.Results Compared with the control group, the BBB rating and synaptophysinⅠmRNA expression was increased in the HBO group and SCI group at each time point ( T3 , T4 , T5 and T6 ) (all P<0.05).Compared with the SCI group, the BBB rating and synaptophysin Ⅰ mRNA expression was increased in the HBO group at each time point (T3, T4, T5 and T6) (all P<0.05).Conclusion HBO promoted the recovery of the injured spinal cord of rats, which may be related with the up-regulation of synaptophysin Ⅰ mRNA expression in the in-jured spinal cord tissues.