山东医药
山東醫藥
산동의약
Shandong Medical Journal
2015年
35期
8-11
,共4页
血小板%淋巴细胞%宫颈鳞状细胞癌
血小闆%淋巴細胞%宮頸鱗狀細胞癌
혈소판%림파세포%궁경린상세포암
blood platelets%lymphocytes%cervical squamous carcinoma
目的：探讨治疗前外周血血小板与淋巴细胞比（ PLR）和宫颈鳞状细胞癌患者预后的关系。方法回顾性分析143例宫颈鳞状细胞癌患者的临床病理资料，根据统计学方法选取PLR截断值，将患者根据截断值分组，分析PLR与宫颈鳞状细胞癌患者生存、复发情况的关系以及与临床病理参数的关系。结果选取PLR＝125作为截断值。 PLR≥125者及PLR＜125者5年生存率分别为54．5％、81．6％，复发率分别为50．0％、22．4％，两组比较，P均＜0．05。 PLR与宫颈鳞状细胞癌患者年龄、FIGO分期、术前化疗、病灶直径、血小板计数有关，患者预后与宫颈鳞状细胞癌FIGO分期、病灶直径、术前有无化疗、PLR、血小板计数有关。 Cox回归分析显示，PLR、FIGO分期、血小板计数、病灶直径、术前是否有化疗是影响是宫颈鳞癌患者术后生存和复发的独立危险因素。结论治疗前外周血PLR与宫颈鳞状细胞癌患者预后有关，其可作为宫颈鳞状细胞癌患者病情评估的指标。
目的：探討治療前外週血血小闆與淋巴細胞比（ PLR）和宮頸鱗狀細胞癌患者預後的關繫。方法迴顧性分析143例宮頸鱗狀細胞癌患者的臨床病理資料，根據統計學方法選取PLR截斷值，將患者根據截斷值分組，分析PLR與宮頸鱗狀細胞癌患者生存、複髮情況的關繫以及與臨床病理參數的關繫。結果選取PLR＝125作為截斷值。 PLR≥125者及PLR＜125者5年生存率分彆為54．5％、81．6％，複髮率分彆為50．0％、22．4％，兩組比較，P均＜0．05。 PLR與宮頸鱗狀細胞癌患者年齡、FIGO分期、術前化療、病竈直徑、血小闆計數有關，患者預後與宮頸鱗狀細胞癌FIGO分期、病竈直徑、術前有無化療、PLR、血小闆計數有關。 Cox迴歸分析顯示，PLR、FIGO分期、血小闆計數、病竈直徑、術前是否有化療是影響是宮頸鱗癌患者術後生存和複髮的獨立危險因素。結論治療前外週血PLR與宮頸鱗狀細胞癌患者預後有關，其可作為宮頸鱗狀細胞癌患者病情評估的指標。
목적：탐토치료전외주혈혈소판여림파세포비（ PLR）화궁경린상세포암환자예후적관계。방법회고성분석143례궁경린상세포암환자적림상병리자료，근거통계학방법선취PLR절단치，장환자근거절단치분조，분석PLR여궁경린상세포암환자생존、복발정황적관계이급여림상병리삼수적관계。결과선취PLR＝125작위절단치。 PLR≥125자급PLR＜125자5년생존솔분별위54．5％、81．6％，복발솔분별위50．0％、22．4％，량조비교，P균＜0．05。 PLR여궁경린상세포암환자년령、FIGO분기、술전화료、병조직경、혈소판계수유관，환자예후여궁경린상세포암FIGO분기、병조직경、술전유무화료、PLR、혈소판계수유관。 Cox회귀분석현시，PLR、FIGO분기、혈소판계수、병조직경、술전시부유화료시영향시궁경린암환자술후생존화복발적독립위험인소。결론치료전외주혈PLR여궁경린상세포암환자예후유관，기가작위궁경린상세포암환자병정평고적지표。
Objective To investigate the correlation between peripheral blood platelet-lymphocyte ratio ( PLR) before treatment and the prognosis in patients with cervical squamous carcinoma.Methods The clinicopathologic data of 143 ca-ses of patients with cervical squamous carcinoma were retrospectively analyzed.According to the statistical method, we se-lected the cut-off value.The patients were divided into different groups based on the cut-off value of PLR.Then we ana-lyzed the relationships of PLR with the prognosis and the reoccurrence of patients with cervical squamous carcinoma and the clinicopathologic parameters.Results We selected PLR=125 as the cut-off value.The 5-year survival rate of high PLR group (PLR≥125) was 54.5%, the 5-year survival rate of low PLR group (PLR<125) was 81.6%;the recurrence rates were respectively 50%and 22.4%;and the difference was statistically significant (all P<0.05).PLR was related with the age of patients, FIGO stage, preoperative chemotherapy, the diameter of the tumor and the number of platelet.The prognosis of patients was related with FIGO stage, the diameter of the tumor, preoperative chemotherapy or not, PLR and the number of platelet.Cox regression analysis showed that PLR, FIGO stage, the number of platelet, the diameter of the tumor and preoperative chemotherapy were the independent risk factors for the survival and prognosis of patients with cervi-cal squamous carcinoma.Conclusion The peripheral blood PLR before treatment is associated with the prognosis of pa-tients with cervical squamous carcinoma, which can be used as the indicator for evaluating cervical squamous carcinoma.
