CAJ | 학술논문

目的：探讨CD44v6与胃癌淋巴结转移及预后的关系。方法采用免疫组织化学方法检测208例胃癌组织和相应癌旁组织中CD44v6蛋白的表达情况，分析CD44v6与胃癌淋巴结转移及预后之间的关系。结果 CD44v6在胃癌中的表达率（59．1％）明显高于癌旁组织（0）。CD44v6表达阳性与阴性患者术后5年生存率分别为38．8％和76．3％，差别有统计学意义（ P＜0．05）。多因素分析提示，CD44v6高表达为胃癌的独立预后因素；CD44v6和浸润深度是淋巴结转移的独立危险因素。分层分析发现，淋巴结有转移者CD44v6表达阳性与阴性的5年生存率分别30．3％和67．7％（P＜0．05），淋巴结无转移者CD44v6表达阳性与阴性的5年生存率分别77．3％和81．8％（P＞0．05）。结论 CD44v6表达阳性的胃癌患者易发生淋巴结转移，预后较差；CD44v6可能成为预测胃癌预后指标之一。
목적：탐토CD44v6여위암림파결전이급예후적관계。방법채용면역조직화학방법검측208례위암조직화상응암방조직중CD44v6단백적표체정황，분석CD44v6여위암림파결전이급예후지간적관계。결과 CD44v6재위암중적표체솔（59．1％）명현고우암방조직（0）。CD44v6표체양성여음성환자술후5년생존솔분별위38．8％화76．3％，차별유통계학의의（ P＜0．05）。다인소분석제시，CD44v6고표체위위암적독립예후인소；CD44v6화침윤심도시림파결전이적독립위험인소。분층분석발현，림파결유전이자CD44v6표체양성여음성적5년생존솔분별30．3％화67．7％（P＜0．05），림파결무전이자CD44v6표체양성여음성적5년생존솔분별77．3％화81．8％（P＞0．05）。결론 CD44v6표체양성적위암환자역발생림파결전이，예후교차；CD44v6가능성위예측위암예후지표지일。
Objective To investigate the relationship between CD44v6 and the lymph node metas‐tasis as well as the prognosis of gastric cancer . Methods The expression level of CD44v6 protein in can‐cerous tissues and the corresponding non‐cancerous tissues in 208 patients with gastric cancer was meas‐ured by immunohistochemistry ,followed by analysis of the relevance between CD44v6 ,lymph nodes me‐tastasis and the prognosis of gastric cancer . Results The expression level of CD44v6 in gastric cancer was 59 .1% ,which was significantly higher than the 0% detected in the paired non‐tumor tissues . The 5‐year survival rate in patients with positive and negative CD44v6 expression was 38 .8% and 76 .3% ,re‐spectively ,with the difference being statistically significant (P<0 .05) . Multivariate analysis demonstra‐ted that high expression of CD44v6 was the independent prognostic factor of gastric cancer ,while CD44v6 and the depth of tumor invasion were the independent risk factors for lymph nodes metastasis . Stratifica‐tion analysis revealed that in patients with lymph nodes metastasis ,the 5‐year survival rate of positive and negative CD44v6 expression was 30 .3% and 67 .7% ,respectively ,whereas in non‐metastasized cases ,the rate was 77 .3% and 81 .8% (P<0 .05) . Conclusion Patients with high expression level of CD44v6 are susceptible to lymph nodes metastasis ,leading to poor outcomes . CD44v6 can be identified as a biomark‐er for predicting the prognosis of gastric cancer .