西北药学杂志
西北藥學雜誌
서북약학잡지
Northwest Pharmaceutical Journal
2015年
5期
638-640
,共3页
刘东芳%张宝琴%冯小军%张成侠%赵晓亮%李素欣%冯志刚%刘艳芬%刘欣%訾建杰
劉東芳%張寶琴%馮小軍%張成俠%趙曉亮%李素訢%馮誌剛%劉豔芬%劉訢%訾建傑
류동방%장보금%풍소군%장성협%조효량%리소흔%풍지강%류염분%류흔%자건걸
右丙亚胺%蒽环类药物%静脉炎
右丙亞胺%蒽環類藥物%靜脈炎
우병아알%은배류약물%정맥염
dexrazoxane%anthracycline%phlebitis
目的：观察右丙亚胺在治疗蒽环类药物诱发化疗性静脉炎中的安全性及有效性。方法65岁男性急性髓细胞白血病（M2a）患者静滴蒽环类药物后，左手背出现红肿、疼痛，先后给予硫酸镁外敷、芦荟外敷、土豆外敷，无效，后静脉注射右丙亚胺治疗（500 mg ，连续5 d）；38岁男性 MDS转急性髓细胞白血病患者给予蒽环类药物后左手背出现红肿、疼痛，即静脉注射右丙亚胺治疗（500 mg ，连续5d）。临床随访（1个月）评定疗效。结果第1例应用右丙亚胺后4d疼痛减轻，7d红肿消退；第2例给予右丙亚胺治疗次日疼痛减轻，3 d红肿消退。2例患者除局部留有轻度色素沉着外，手及前臂功能无影响。结论右丙亚胺治疗蒽环类药物诱发静脉炎行之有效，尽早应用，疗效更佳。
目的：觀察右丙亞胺在治療蒽環類藥物誘髮化療性靜脈炎中的安全性及有效性。方法65歲男性急性髓細胞白血病（M2a）患者靜滴蒽環類藥物後，左手揹齣現紅腫、疼痛，先後給予硫痠鎂外敷、蘆薈外敷、土豆外敷，無效，後靜脈註射右丙亞胺治療（500 mg ，連續5 d）；38歲男性 MDS轉急性髓細胞白血病患者給予蒽環類藥物後左手揹齣現紅腫、疼痛，即靜脈註射右丙亞胺治療（500 mg ，連續5d）。臨床隨訪（1箇月）評定療效。結果第1例應用右丙亞胺後4d疼痛減輕，7d紅腫消退；第2例給予右丙亞胺治療次日疼痛減輕，3 d紅腫消退。2例患者除跼部留有輕度色素沉著外，手及前臂功能無影響。結論右丙亞胺治療蒽環類藥物誘髮靜脈炎行之有效，儘早應用，療效更佳。
목적：관찰우병아알재치료은배류약물유발화료성정맥염중적안전성급유효성。방법65세남성급성수세포백혈병（M2a）환자정적은배류약물후，좌수배출현홍종、동통，선후급여류산미외부、호회외부、토두외부，무효，후정맥주사우병아알치료（500 mg ，련속5 d）；38세남성 MDS전급성수세포백혈병환자급여은배류약물후좌수배출현홍종、동통，즉정맥주사우병아알치료（500 mg ，련속5d）。림상수방（1개월）평정료효。결과제1례응용우병아알후4d동통감경，7d홍종소퇴；제2례급여우병아알치료차일동통감경，3 d홍종소퇴。2례환자제국부류유경도색소침착외，수급전비공능무영향。결론우병아알치료은배류약물유발정맥염행지유효，진조응용，료효경가。
Objective The purpose of this study was to assess the efficiency and safety of the treatment of anthracyclines induced phlebitis with dexrazoxane .Methods The first case was a 65 year‐old male patient with acute myelogenous leukemia (M2a) .His left back appeared redness swollen ,and pain after giving anthracyclines .The successively external application with magnesium sul‐fate ,aloe ,and potatoes was ineffective ,then dexrazoxane (500 mg ,5 d) was given intravenously ;The second case was a 38 year‐old male patient with acute myelogenous leukemia transferred by MDS .His left back appeared redness ,swollen ,and pain after giv‐ing anthracyclines dexrazoxane (500 mg ,5 d) .The curative effect was evaluated by clinical follow‐up(1 month) .Results After giving dexrazoxane intravenously ,pain was relieved ,and red faded ,no side effects observed .Conclusion Giving dexrazoxane in‐travenously for phlebitis induced by anthracyclines ,is an effective method .
