CAJ | 학술논문

以水难溶性药物布洛芬（IB ）为模型，聚氧化乙烯（PEO ）与玉米淀粉（S T ）为载体，利用高压静电纺丝的方法制备固体分散体。利用扫描电镜观察到纳米纤维成连续三维立体网状结构。红外光谱分析表明， IB、PEO 和S T 三者之间能够通过氢键相互作用。X射线衍射分析结果表明，含有少量药物时IB是以无定形或分子状态高度分散于聚合物中，增大药物含量时，会有少量晶体析出。体外溶出试验结果表明，载药纳米纤维状固体分散体载药量越大，释放时间越长。而载药量相同，纤维状纳米固体分散体中淀粉质量分数越大，释药速率越大，释放时间越短。
이수난용성약물포락분（IB ）위모형，취양화을희（PEO ）여옥미정분（S T ）위재체，이용고압정전방사적방법제비고체분산체。이용소묘전경관찰도납미섬유성련속삼유입체망상결구。홍외광보분석표명， IB、PEO 화S T 삼자지간능구통과경건상호작용。X사선연사분석결과표명，함유소량약물시IB시이무정형혹분자상태고도분산우취합물중，증대약물함량시，회유소량정체석출。체외용출시험결과표명，재약납미섬유상고체분산체재약량월대，석방시간월장。이재약량상동，섬유상납미고체분산체중정분질량분수월대，석약속솔월대，석방시간월단。
The nanofibers loaded with slightly soluble drug‐ibuprofen(IB) as solid dispersion were prepared by electrospinning technology with poly ethylene oxide (PEO) and corn starch (ST) as the carrier .A three‐dimen‐sional continuous network structure of the nanofibers was observed by scanning electronic microscopy .The hy‐drogen bonding interactions among IB ,PEO and ST were demonstrated by infrared spectroscopy .The results of X‐ray diffraction suggested that IB was highly distributed in the nanofibers at an amorphous status or a molecu‐lar state when the drug content was small .There will appear some crystal precipitation when the drug content increases .T he results of in vitro dissolution test show ed that w hen the drug content of nanofiber increased ,the release time of IB will longer .When the drug content was constant ,along the ST content increase ,the release rate will increase and the release time will decrease .