CAJ | 학술논문

目的：探讨齐拉西酮、利培酮对精神分裂症阴性症状和认知功能的影响。方法选取2013年1—9月佛山市顺德区伍仲佩纪念医院住院部所收治的75例精神分裂症患者为研究对象，随机分为齐拉西酮组（n＝39）和利培酮组（n＝36），分别给予齐拉西酮和利培酮治疗8周。采用精神病阴性与阳性症状量表（ PANSS）、韦氏记忆量表（ WMS）、威斯康星卡片分类测验（ WCST）分别于治疗前及治疗8周后对两组进行评定。结果治疗8周后，齐拉西酮组与利培酮组总体疗效无显著差异（P＞0．05），齐拉西酮组精神病阴性症状量表、韦氏记忆测验、威斯康星卡分类测验多项成绩优于治疗前和利培酮组（ P＜0．05）。结论齐拉西酮比利培酮更有助于阴性症状和认知功能的改善。
목적：탐토제랍서동、리배동대정신분렬증음성증상화인지공능적영향。방법선취2013년1—9월불산시순덕구오중패기념의원주원부소수치적75례정신분렬증환자위연구대상，수궤분위제랍서동조（n＝39）화리배동조（n＝36），분별급여제랍서동화리배동치료8주。채용정신병음성여양성증상량표（ PANSS）、위씨기억량표（ WMS）、위사강성잡편분류측험（ WCST）분별우치료전급치료8주후대량조진행평정。결과치료8주후，제랍서동조여리배동조총체료효무현저차이（P＞0．05），제랍서동조정신병음성증상량표、위씨기억측험、위사강성잡분류측험다항성적우우치료전화리배동조（ P＜0．05）。결론제랍서동비리배동경유조우음성증상화인지공능적개선。
Objective To explore the efficacy of ziprasidone and risperidone for improving negative symptom and cognitive function in schizophrenia.Methods In this study, we enrolled 75 schizophrenia patients in our hospital from January 2013 to September 2013.These patients were divided into ziprasidone group ( n=39) and risperidone group ( n =36 ) .Positive and Negative Symptom Scale ( PANSS ) , Wechsler Memory Scale ( WMS) , Wisconsin Card Sorting Test ( WCST) were employed to assess negative symptom and cognitive function before and after treatment respectively for 8 weeks.Results After treatment for 8 weeks, there were nosignificant differences on overall effect between the two groups ( P>0.05) and all the results of PANSS, WMS and WCST in ziprasidone group were significantly better than before treatment and risperidone group (P<0.05). Conclusions Compared with risperidone, ziprasidone can remarkable improve the negative symptom and cognitive function in patients with schizophrenia.