CAJ | 학술논문

目的：比较红霉素、阿奇霉素序贯疗法与单用阿奇霉素治疗小儿肺炎支原体肺炎的疗效。方法收集2014年1月～2015年1月确诊的肺炎支原体肺炎患儿116例进行研究，并按照就诊顺序随机分为两组。对照组58例患者单独予阿奇霉素治疗，观察组58例患者予红霉素联合阿奇霉素序贯疗法治疗，分析并比较临床治疗效果及不良反应情况。结果观察组总有效率（96.55%）高于对照组（81.03%）（P＜0.05）。观察组患儿退热时间、咳嗽消失时间、肺部啰音消失时间及住院时间与对照组比较均明显缩短，差异有统计学意义（P＜0.05）。观察组不良反应发生率（13.79%）低于对照组（34.48%），差异有统计学意义（P＜0.05）。结论红霉素联合阿奇霉素序贯疗法用于小儿肺炎支原体肺炎的治疗效果显著，用药安全性高。
목적：비교홍매소、아기매소서관요법여단용아기매소치료소인폐염지원체폐염적료효。방법수집2014년1월～2015년1월학진적폐염지원체폐염환인116례진행연구，병안조취진순서수궤분위량조。대조조58례환자단독여아기매소치료，관찰조58례환자여홍매소연합아기매소서관요법치료，분석병비교림상치료효과급불량반응정황。결과관찰조총유효솔（96.55%）고우대조조（81.03%）（P＜0.05）。관찰조환인퇴열시간、해수소실시간、폐부라음소실시간급주원시간여대조조비교균명현축단，차이유통계학의의（P＜0.05）。관찰조불량반응발생솔（13.79%）저우대조조（34.48%），차이유통계학의의（P＜0.05）。결론홍매소연합아기매소서관요법용우소인폐염지원체폐염적치료효과현저，용약안전성고。
Objective To compare the therapeutic effect of erythromycin, azithromycin sequential therapy with azithromycin in treatment of mycoplasma pneumonia in children. Methods 116 children with mycoplasma pneumonia were studied January 2014 ~ January 2015, and were randomly divided into two groups according to the order of treatment. In the control group, 58 patients were treated with azithromycin alone, the observation group was treated with erythromycin combined with azithromycin in the treatment of 58 cases. The clinical efifcacy and adverse reactions were analyzed and compared. Results The total effective rate in the observation group was higher (96.55%) than that in the control group (81.03%) (P<0.05). The group, fever, cough disappeared time, pulmonary rales disappearance time and hospitalization time and the control group was shorten observation of the, the difference was statistically signiifcant (P<0.05). The incidence of adverse reactions in observation group (13.79%)was lower than that in the control group (34.48%), the difference was statistically signiifcant (P<0.05). Conclusion Erythromycin combined with azithromycin sequential therapy for children with mycoplasma pneumonia, the treatment effect is obvious, the safety of medicine is high.