CAJ | 학술논문

年龄相关性黄斑变性和色素性视网膜炎等视网膜变性疾病可造成光感受器丢失,从而导致永久性的视力损害.近年来诸多研究致力于研究支架材料在视网膜细胞移植中的应用.支架材料能靶向运输移植细胞,促进细胞的存活、整合和分化,为细胞移植提供良好的平台.移植细胞种类多样,不同的支架材料具有各自的优缺点,理想的支架材料应具备以下特性:薄、生物相容性好、可降解、一定的机械强度、柔韧性高、可结合性高.材料的表面修饰可帮助其更好地发挥功能.除了细胞,支架材料也可定向运输物质,如药物等.支架材料在视网膜细胞移植中具有良好的应用前景.本文总结了以输送细胞到视网膜下腔的不同支架材料为基础的移植技术的研究成果.
년령상관성황반변성화색소성시망막염등시망막변성질병가조성광감수기주실,종이도치영구성적시력손해.근년래제다연구치력우연구지가재료재시망막세포이식중적응용.지가재료능파향운수이식세포,촉진세포적존활、정합화분화,위세포이식제공량호적평태.이식세포충류다양,불동적지가재료구유각자적우결점,이상적지가재료응구비이하특성:박、생물상용성호、가강해、일정적궤계강도、유인성고、가결합성고.재료적표면수식가방조기경호지발휘공능.제료세포,지가재료야가정향운수물질,여약물등.지가재료재시망막세포이식중구유량호적응용전경.본문총결료이수송세포도시망막하강적불동지가재료위기출적이식기술적연구성과.
Retinal degeneration,associated with loss of photoreceptors,is the primary cause of permanent vision impairment,impacting millions of people worldwide.Age-related macular degeneration and retinitis pigmentosa are two common retinal diseases resulting in photoreceptor loss.Recently,many studies were working on the application of polymer scaffolds in retinal stem cell transplantation.The results showed that polymer scaffolds can delivery transplanted cells to the correct site and promote cell survival,integration,differentiation,thereby providing a good platform for cell transplantation.There are different transplantation cell types.Moreover,different materials have different advantages and disadvantages.The ideal scaffold should have the following characteristics:thin,biocompatible,biodegradable,certain mechanical strength and flexibility,and easy to bind.Surface modification of materials can improve their functioning.In addition to the cells,the scaffold can directional transport substances,such as drugs.Polymer scaffolds have a good prospect in the application of retinal cell transplantation.This paper summarized the findings of different scaffolds for cell delivery to the sub-retinal space-based transplant technology.